Organic Free Radical Chemistry

本研究的重点是自由基动力学和机理研究。 纽科姆博士将开展几个项目， 激光闪光光解和反应的间接动力学测量 各种激进分子。 一个目标是创造动力学尺度， 取代的碳基团和杂原子中心基团， 补充了简单烷基的高度发达的规模，部分 的工作是针对具体的重要目标，如 DNA自由基反应动力学 此外，还将强调 关于超快自由基重排的研究 有了这个更新奖， 有机动力学计划正在支持马丁·E· 州立大学韦恩化学系的纽科姆说。 纽科姆教授将把他的工作重点放在探索动力学和 碳自由基中间体的机械性质。 更好的 对这些领域的理解将导致扩大方法， 合成化学家和知识，将承担一些重要的 生物过程。

The focus of this research is radical kinetic and mechanistic studies. Dr. Newcomb will carry out several projects that involve both direct, laser flash photolysis and indirect kinetic measurements of reactions of a variety of radicals. One aim is to create kinetic scales for substituted carbon radicals and heteroatom-centered radicals that complement the highly developed scale for simple alkyl radicals, and part of the work is directed at specific important targets such as the kinetics of DNA radical reactions. In addition, emphasis will be placed on studies of ultrafast radical rearrangements. With this renewal award, the Organic Dynamics Program is supporting the research of Dr. Martin E. Newcomb of the Department of Chemistry at Wayne State University. Professor Newcomb will focus his work on probing the kinetic and mechanistic properties of carbon radical intermediates. A better understanding in these areas will lead to expanded methodology for synthetic chemists and knowledge that will bear on a number of vital biological processes.