Synthesis and Metabolism of Chlorophylls and Derivatives

本研究的重点是对合成和 叶绿素及其衍生物的代谢。 生物合成的起源 将研究细菌叶绿素e中的大环碳， 研究了衰老细菌中分子的降解。 综合研究的目的是生产各种目标 包括3，8-二乙烯基叶绿素-a、异叶绿素-a、构象上 锁定的光敏色素和一系列非平面卟啉， 氯 稳定的根皮素和corroles也将构建与 目标是生产双大环化合物。有了这个奖项，合成有机 该项目支持Kevin M博士的研究。的史密斯 加州大学戴维斯分校化学系。 博士 史密斯将把他的工作重点放在一个基础广泛，范围广泛的研究， 新卟啉的生物合成、催化、化学和光谱学， 叶绿素和细菌叶绿素。 叶绿素是催化剂 在光合作用的重要过程中， 收集以及电荷分离的过程。 某些 卟啉和它们的金属配合物将作为 叶绿素存在于光合生物中，并作为分子 潜在的生物医学影响。

The focus of this research is a broad study on the syntheses and metabolism of chlorophylls and derivatives. The biosynthetic origin of macrocyclic carbons in the bacteriochlorophyll-e will be investigated and the degradation of the molecules in senescent bacteria studied. Synthetic studies will be aimed at the production of a variety of targets including 3,8-divinylchlorophyll-a, isochlorophyll-a, a conformationally locked phytochromobilin and a series of non-planar porphyrins and chlorins. Stable phlorins and corroles will also be constructed with the goal of producing bis-macrocycles. With this award, the Synthetic Organic Program is supporting the research of Dr. Kevin M. Smith of the Department of Chemistry at the University of California, Davis. Dr. Smith will focus his work on a broad-based and wide-ranging study of the biosynthesis, catabolism, chemistry and spectroscopy of novel porphyrins, chlorophylls and bacteriochlorophylls. Chlorophylls are the catalysts in the vital process of photosynthesis and are involved in light gathering as well as the process of charge separation. Certain porphyrins and their metal complexes are to be studied as biomimics of chlorophylls found in photosynthetic organisms and as molecules with potential biomedical implications.