Nitrosyl and Nitroso Metalloporphyrins

George Richter-Addo博士，俄克拉何马大学化学系，由化学系无机、生物无机和有机金属项目资助，并获得教师早期职业发展奖，研究亚硝基和亚硝基金属卟啉。一氧化氮是一种大气污染物，在一些生物合成途径中起着重要作用。有机亚硝基化合物可能在一氧化氮反应中起生理介质的作用。将合成金属卟啉配合物，并研究其与金属中心的化学反应和相互作用模式。培养计划的目标是让本科生参与研究，设计金属卟啉合成的实验室实验，开设本科生物无机课程。这项研究的总体目标是检查生物重要分子金属卟啉的合成类似物的反应。这些分子由一个被氮原子和碳原子环包围的金属离子组成，在生物系统中无处不在，并已被发现与一氧化氮及其衍生物发生反应。一氧化氮是一种大气污染物，有机亚硝基化合物是在一些食物和香烟烟雾中发现的致癌物。这种化学有可能更好地理解金属卟啉与一氧化氮在生理系统中的相互作用。教育计划侧重于本科研究和开发新的实验室实验和课程，强调无机化学的生物学意义。

Dr. George Richter-Addo, Department of Chemistry, University of Oklahoma, is supported by the Inorganic, Bioinorganic, and Organometallic Program of the Chemistry Division under a Faculty Early Career Development Award for studies of nitrosyl- and nitroso-metalloporphyrins. Nitric oxide is an atmospheric pollutant and it plays an important role in some biosynthetic pathways. Organic nitroso compounds may play a role as physiological mediators in reactions of nitric oxide. Metalloporphyrin complexes will be synthesized, and the chemical reactions and modes of interaction with the metal centers will be investigated. The education plan is aimed at involving undergraduate students in research, designing laboratory experiments involving metalloporphyrin synthesis, and developing an undergraduate bioinorganic course. The overall goal of this research is to examine the reactions of synthetic analogues of biologically important molecules known as metalloporphyrins. These molecules, which consist of a metal ion surrounded by a ring of nitrogen and carbon atoms, are ubiquitous in biological systems and have been found to react with nitric oxide and its derivatives. Nitric oxide is an atmospheric pollutant, and organic nitroso compounds are carcinogens found in some food and in cigarette smoke. This chemistry has the potential to provide a better understanding of the role of the interactions of metalloporphyrins with nitric oxides in physiological systems. The education plan focuses on undergraduate research and the development of new laboratory experiments and courses which emphasize the biological significance of inorganic chemistry.