Molecular Recognition Using Organoboron Acids

在有机动力学项目的资助下，圣母大学的史密斯教授正在研究有机硼酸的化学，涉及碳水化合物异构化、膜运输、药物输送和作为阴离子受体。这项研究的主要重点是通过使用具有高度选择性的硼酸来促进葡萄糖转化为果糖。更多的努力是通过使用对果糖具有高度选择性的膜传输复合体来提高浓度。人们正在研究新类型的有机硼酸衍生物，因为它们能够选择性地促进葡萄糖异构化为果糖。此外，这些硼酸衍生物正被用作果糖选择性膜传输的试剂、儿茶酚胺分析的试剂、药物输送载体和Lewis酸催化反应中的阴离子受体。

With funding from the Organic Dynamics Program, Professor Smith of the University of Notre Dame is investigating the chemistry of organoboronic acids with regard to carbohydrate isomerization, membrane transport, drug delivery, and as anion receptors. The major focus of the investigation is to facilitate the conversion of glucose to fructose by using boronic acids that are highly selective. Additional efforts are directed at concentration enhancement through the use of membrane transport complexes that are highly selective for fructose. New classes of organoboronic acid derivatives are being investigated for their ability to selectively facilitate the isomerization of glucose to fructose. Further, these boronic acid derivatives are being investigated as reagents for selective membrane transport of fructose, as reagents for the analysis of catecholamines, as drug delivery vehicles, and anion receptors in Lewis acid catalysis reactions.