Organometallic Reaction Mechanisms

该奖项在无机，生物无机和有机化学 该计划支持有机金属反应机制的研究， 威斯康星州大学化学系的查尔斯·P·凯西博士 在麦迪逊。 将开展三个不同的研究领域： d-0钇和锆烯烃络合物的研究.发展 炔丙基金属络合物的化学;以及β-卡宾的化学 配合物 为第一个调查领域选择的系统将 允许测量烯烃解离速率和 在金属中心的反转。 这些信息对于 了解聚合的立体化学与手性 茂金属催化剂 炔丙基的三种合成方法 络合物将被研究，以及亲核试剂的反应 与这些配合物，这已被证明是有用的有机 合成. HCl对β-卡宾加成反应的立体化学 配合物将被研究，沿着一些不寻常的形成 复合物，旨在提供有关联合模式的信息， 含双键碳化合物的金属和关于使用 环应变，以有利于形成所需的产品。 有机化学已被证明是非常有用的均相 催化和开发新的方法和试剂合成 有机化合物 选择用于研究的反应是相关的 商业上重要的过程的行为。

This award in the Inorganic, Bioinorganic, and Organometallic Chemistry Program supports research on mechanisms of organometallic reactions by Dr. Charles P. Casey of the Chemistry Department, University of Wisconsin at Madison. Three distinct areas of research will be pursued: investigations of d-0 yttrium and zirconium olefin complexes; development of pi-propargyl metal complexes; and the chemistry of rhenium carbene complexes. The systems chosen for the first area of investigation will permit measurement of the rate of alkene dissociation and the rate of inversion at the metal center. This information is important for understanding the stereochemistry of polymerization with chiral metallocene catalysts. Three methods of synthesis of the pi-propargyl complexes will be investigated, as well as the reaction of nucleophiles with these complexes, which have been shown to be useful in organic synthesis. The stereochemistry of addition of HCl to rhenium carbene complexes will be studied, along with the formation of some unusual complexes designed to give information about modes of association of metals with double-bonded carbon compounds and about using variation in ring strain to favor formation of desired products. Organometallic chemistry has proved to be very useful in homogeneous catalysis and in developing new methods and reagents for synthesis of organic compounds. The reactions chosen for investigation are relevant to the behavior of commercially important processes.