Catalysts for Asymmetric Phosphonylation and Synthetic Applications

本研究的重点是开发醛的不对称膦酰化反应合成光学纯度较高的α-羟基膦酰胺的催化剂。此外，还将制备烯丙基羟基膦酸酯，并将该方法应用于酶抑制剂的制备。通过这一奖项，合成有机计划支持密苏里大学圣路易斯分校化学系的克里斯托弗·D·斯皮林博士的研究。斯皮林教授将专注于开发合成方法来制备α-羟基膦酰胺，这是一类具有重要生物活性的化合物。

The focus of this research is the development of catalysts for the asymmetric phosphonylation of aldehydes to form alpha-hydroxyphosphonamides of high optical purity. In addition, allylic hydroxyphosphonates will be prepared and the methodology will be applied to the preparation of enzyme inhibitors. With this award, the Synthetic Organic Program is supporting the research of Dr. Christopher D. Spilling of the Department of Chemistry at the University of Missouri, St. Louis. Professor Spilling will focus his work on the development of synthetic methodology for the preparation of alpha-hydroxyphosphonamides, a class of compounds having important biological activity.