Synthesis of Vitamin K Models

有了这个更新奖，有机动力学计划正在支持 匹兹堡大学多德教授的研究成果。的焦点 这项研究详细了解了维生素A K是羧化酶的辅因子。该系统负责 激活凝血级联反应的蛋白质本研究 包括详细说明维生素K是如何氧化的， 或不是二烷氧基二价阴离子是该途径的组成部分。一个 另一个目标是建立维生素K和E之间的关系 关于后者作为维生素K的抑制剂， 通路 维生素K是凝血维生素。因此，这是一种义务。 羧化酶的辅因子，负责激活 凝血级联的蛋白质。 多德教授将专注于 维生素K的作用途径的机制细节， 促进血液凝固过程

With this renewal award, the Organic Dynamics Program is supporting the work of Professor Dowd from the University of Pittsburgh. The focus of this research is a detailed understanding of the pathway used by vitamin K which is a cofactor for carboxylase. This system is responsible for activating the proteins for the blood-clotting cascade. The study is to include elaborating the details of how vitamin K is oxidized and whether or not dialkoxy dianions are an integral part of the pathway. An additional goal is to establish the relationship between Vitamins K and E with regard to the latter acting as an inhibitor of the Vitamin K pathway. Vitamin K is the blood-clotting vitamin. As such, it is an obligatory cofactor for a carboxylase that bears responsibility for activating the proteins of the blood-clotting cascade. Professor Dowd is to focus on the mechanistic details of the pathway followed by vitamin K when it facilitates the blood-clotting process.