New Techniques for NMR Studies of Structure and Dynamics in Membrane Mimetics and Paramagnetic Materials

在这个项目中，在实验物理化学计划的 Regitze Vold化学部将开发核磁共振新技术 固体和有序相的分子结构和动力学的研究。 这些研究的重点是无机的，生物无机的， 重要的生物系统。 具体项目包括 新型磁对准盘状晶体研究 磷脂双层胶束（bicelles），一种多核自旋 松弛研究，以测试松弛和内部运动的模型， 有序双胞中的膜相关肽， 线粒体氧化还原辅因子的结构和动力学研究 磷脂双层中的Q10（泛醌）和魔角纺丝（MAS） 顺磁性无机和生物无机模型化合物的实验。 该项目实验的共同主题是扩展和 将核磁共振波谱学应用于化学结构和动力学问题 这将提供有关结合，构象， 生物学相关分子的动力学以及固体 过渡金属配合物 在这项工作中开发的方法 将有助于增加固体核磁共振对结构生物学的影响。

In this project in the Experimental Physical Chemistry Program of the Chemistry Division, Regitze Vold will develop new techniques for the NMR study of molecular structure and dynamics of solids and ordered phases. The emphasis in these studies is on inorganic, bioinorganic, and biologically important systems. Specific projects include the investigation of novel, magnetically aligned discoidal nematic phospholipid bilayered micelles (bicelles), a multi-nuclear spin relaxation study to test models of relaxation and internal motion of membrane-associated peptides in ordered bicelles, the continuation of studies of the structure and dynamics of the mitochondrial redox cofactor Q10 (ubiquinone) in phospholipid bilayers, and magic angle spinning (MAS) experiments on paramagnetic inorganic and bioinorganic model compounds. The common theme of the experiments in this project is to extend and apply NMR spectroscopy to structural and dynamic problems in chemistry which will provide information about the binding, conformation, and dynamics of biologically relevant molecules as well as about solid transition-metal complexes. The approaches being developed in this work will help increase the impact of solid-state NMR on structural biology.