Dielectric Studies of Proteins

9701453波拉克这是研究蛋白质介电特性的女性职业成就奖。这些实验的目的是研究蛋白质形状（构象）和蛋白质折叠的重要问题，蛋白质折叠是氨基酸线性链呈现形状的过程，使蛋白质能够执行其特定功能。蛋白质的折叠中间体将用不同的技术进行研究，例如测量蛋白质溶液的介电常数。介电常数是测量大分子内电荷分布的一种方法，当蛋白质折叠时介电常数会发生变化。膜蛋白也将被研究。这是一个研究蛋白质介电特性的女性职业成就奖。蛋白质是由长链氨基酸组成的大分子。这种分子将自己“折叠”成特定的形状，决定了它的功能。这些实验的目的是深入了解蛋白质形状（构象）和蛋白质折叠的重要问题。不同的技术，比如对分子中正电荷和负电荷分布的详细测量，可以获得有关导致蛋白质以独特方式折叠的力的新信息。不同类型的蛋白质将被研究，包括跨膜的重要蛋白质。＊＊＊

9701453 Pollack This is a Woman Career Advancement Award to study the dielectric properties of proteins. The goal of these experiments is to study the important problems of protein shape (conformation) and protein folding, the process by which a linear chain of amino acids assumes the shape which allows the protein to perform its specific function. Folding intermediates of proteins will be studied with different techniques, such as measurements of the dielectric constant of a protein solution. The dielectric constant is a measure of the distribution of charge within the macromolecule and changes as the protein folds. Membrane proteins will also be studied. %%% This is a Woman Career Advancement Award to study the dielectric properties of proteins. Proteins are large molecules that consist of a long chain of amino acids. The molecule 'folds' itself into a specific shape that dictates its function. The goal of these experiments is to gain insight into the important problems of protein shape (conformation) and protein folding. Different techniques, such as a detailed measurements of the distribution of positive and negative charges in the molecule, can yield new information about the forces that cause the protein to fold in a unique way. Different types of proteins will be studied, including the important class of proteins that cross membranes. ***