New Avenues for the Intramolecular Diyl Trapping Reaction

这项研究的重点将是利用双自由基化学开发新的合成方法。将探讨三亚甲基甲烷(TMM)二基的原子转移化学、(4+3)-环加成对TMM二自由基的作用以及乙烯基环丙基取代的TMM二基的裂解/环化反应。已经选择了适当的合成目标来展示该方法。有了这一续期奖，合成有机计划将支持加州大学圣巴巴拉分校化学系R.Danial Little博士的研究努力。利特尔教授将把工作重点放在开发涉及双自由基的三个过程上。将探索原子转移反应、与1，3-二烯的反应和裂解-环化反应，以开发构建感兴趣的天然产物的新方法。

The focus of this research will be the development of new synthetic methodology using diradical chemistry. Atom transfer chemistry of trimethylenemethane (TMM) diyls, (4+3) - cycloadditons to TMM diradicals and fragmentation/cyclization of vinylcyclopropyl substituted TMM diyls will be probed. Appropriate synthetic targets have been chosen to showcase the methodology. With this renewal award, the Synthetic Organic Program is supporting the research efforts of Dr. R. Danial Little of the Department of Chemistry at the University of California, Santa Barbara. Professor Little will focus his work on developing three processes involving diradicals. Atom transfer reactions, reactions with 1,3-dienes and fragmentation-cyclization reactions will all be explored in order to develop new methodology for the construction of interesting natural products.