Central Components of Sympathetic Pathways

Lay Abstract PI：Caron Dean-Bernhoft，Ph.D.提案编号：IBN-9723348在心脏和血管中发生的变化在许多条件下维持血压是不同的，因为身体的要求并不总是相同的。 例如，在对抗期间，心率和流向活动肌肉的血液必须上升，但流向肾脏的血液可能会减少。 另一方面，当天气变冷时，流向皮肤的血液减少，而流向内脏的血液增加以保持热量。 这些类型的心率和血流变化是由大脑中一个叫做RVLM的特定部分调节的。 这项研究探讨了RVLM的这些神经细胞如何协调神经活动，以调节心血管系统在不同的行为状态。 特别注意的是从细胞释放的化学物质在这一领域的调节该中心的活动的特点，从而改变心血管活动的模式。这项研究的结果有助于了解在不同或紧急情况下如何调整血流和血压以满足身体的需求。 这些信息对于更深入地了解血压是如何控制的至关重要。

Lay Abstract PI: Caron Dean-Bernhoft, Ph.D. Proposal Number: IBN-9723348 The changes that take place in the heart and blood vessels to maintain blood pressure under a number of conditions are different, since the requirements of the body are not always the same. For example, during confrontations, heart rate and blood flow to the active muscles must go up but blood flow to the kidney can be reduced. On the other hand, when it gets cold, blood flow to the skin decreases while flow to internal organs increases to retain heat. These types of changes in heart rate and blood flow are regulated by a specific part of the brain called the RVLM. This study examines how these nerve cells of the RVLM coordinate nerve activity to regulate the cardiovascular system during different behavioral states. Particular attention is paid to the characteristics of the chemical substances released from cells in this area that modulate the activity of this center, and thus change the pattern of cardiovascular activity. The results from this study contribute to understanding how blood flow and blood pressure are adjusted to meet the needs of the body under different or emergency situations. Such information is fundamental to a deeper understanding of how blood pressure is controlled.