A New Class of "Heteroscorpionate" Ligands for Inorganic Chemistry

该奖项在无机，生物无机和有机 化学计划支持卡尔教授实验室的研究 德克萨斯西南州立大学的J. Carrano在一项关于 研究在本科院校。 本研究将探讨 “蝎子”化合物化学。 蝎子是 三吡唑硼酸盐和-甲烷配体，它们是表面配位的 并稳定各种氧化态的金属。 一般 异蝎形配体的合成路线，其将引入 生物相关供体（硫醇、苯酚、羧酸盐等）为 “刺”尾沿着与两个吡唑基“爪，”将发展。 的 这些配体的表面配位性质与 杂原子的引入将为研究这些化合物提供基础。 作为蛋白质中金属离子活性位点的模型的化合物，例如， 腈水合酶 这项研究在一个主要的本科院校将 进行新的配合物与配体的制备， 化合物作为模型的金属中心的活性位点， proteins.

This award in the Inorganic, Bioinorganic and Organometallic Chemistry program supports research in the laboratory of Professor Carl J. Carrano at Southwest Texas State University under the initiative on Research at Undergraduate Institutions. This research will explore the chemistry of `scorpionate` complexes. Scorpionates are trispyrazoly-borate and -methane ligands, which are facially coordinating and stabilize metals in a variety of oxidation states. A general synthetic route into heteroscorpionate ligands, which would incorporate a biologically relevant donor (thiol, phenol, carboxylate, etc.) as the `stinger` tail along with two pyrazolyl `claws,` will be developed. The facially coordinating nature of these ligands together with the introduction of heteroatoms will provide the basis for studying these compounds as models for metal ion active sites in proteins, such as as nitrile hydratase. This research at a primarily undergraduate institution will undertake the preparation of new complexes with ligands that will allow the compounds to serve as models for metal-centered active sites in proteins.