Chemistry of Singlet Oxygen and Related Topics

本研究的重点是表征单线态氧的化学性质，特别强调它与烯烃和二烯的反应。作为反应条件的函数并与瞬态中间体相关的产物产率将用于开发一种方案来预测和控制这种无处不在的亚稳态氧形式的反应。本课程将向本科生、研究生和博士后介绍这种能量形式的氧的化学性质，并通过发展表征单线态氧延迟荧光所需的方法，以及用于探索其性质的快速反应技术。通过这个奖项，有机和大分子化学项目支持加州大学洛杉矶分校化学和生物化学系的Christopher S. Foote博士的研究。富特教授将开发方法来预测和控制一种被称为单线态氧的高能氧的化学反应，这种氧目前与暴露在阳光下的皮肤老化、白内障诱发和光致癌有关。Foote教授的研究将向本科生、研究生和博士后学生介绍这种高能氧的化学形式，以及表征瞬态中间体特性的技术。╣¥职权范围│¢职权范围¥©Á /¢¥¼©Á - Á¥%%││？│││¥¥/ 0.00¥职权范围│职权范围/¥？╣¥©Á À <e:1> ？？/╣╝一¢¥吗?/¢/_ _ _ _ %Á¢-│Á ' ？ _Á_烧烧Á ？ Á/│©¿/ ？一个吗?_/% %╣ÂÁ©╣¢¥？╝╣一¢┴╣% %▓一个%╣│╣¥┤╝?_/¢_/%%Á - _烧段Á ？ _Á_烧烧Á  _Á_¢¼©╣¢<e:1> Á¢Á/││©<e:1>╣%% Á/ ？┐╝,?┴%┤AA ?Â¥©╣¢_ _ _ _ _ _ _ ？╝¥/¥╝AA╣吗?？Â¥©Á Á ？│% <e:1> / <e:1>点/│Á¥©Á¥<e:1> /╣À ？ / ' ？┐¢吗?│╣/%¢│Á¥╣¢¥/│_╣Á Á <e:1>,？┤AA /▓┴% ?-¥│©/ÀÁ¢╣<e:1> /│Á /¢/ ？→À/╣：À→╣│╣%Á→í→│╣¥”

This research focuses on characterizing the chemistry of singlet oxygen with a specific emphasis on its reactions with alkenes and dienes. Product yields, determined as a function of reaction conditions, and correlated with transient intermediates, will be used to develop a protocol to predict and control the reactions of this ubiquitous, metastable form of oxygen. Undergraduate, graduate and postdoctoral students will be introduced to the chemistry of this energetic form of oxygen and, through the development of the methods needed to characterize singlet oxygen delayed fluorescence, the fast reaction techniques used to explore its properties. With this award, the Organic and Macromolecular Chemistry Program supports the research of Dr. Christopher S. Foote of the Department of Chemistry and Biochemistry at the University of California, Los Angeles. Professor Foote will develop methods to predict and control the chemistry of an energetic form of oxygen, called singlet oxygen, that is currently implicated in the aging of sun-exposed skin, cataract induction, and photocarcinogenesis. Professor Foote's research will introduce undergraduate, graduate and postdoctoral students to the chemistry of this energetic form of oxygen, and to the techniques to characterize the properties of transient intermediates. ╣¥╣│¢ ╣ ¥©Á ║/¢¥ ¼©Á ¢¥┐┤Á¥ ┴╣%% │?┤┐│¥ ║/╝¥╣│╣║/¥ ?▓¢Á╝└/¥╣? ╣ ¥©Á À╝?┐║¢ /¢ ┴Á%% /¢ /┤_╣╣¢¥Á╝ ╗┐Á¢¥╣?/╣╝Á¢ ¥? / ¢/_║%Á ¢┐╝└Á` ? _Á_▓Á╝¢ ? Á/│© ¿ /┤┤╣¥╣? Â?╝_/% %╣ÂÁ ©╣¢¥?╝╣Á¢ ┴╣%% ▓Á Á%╣│╣¥Á┤ Â╝?_ / ¢_/%%Á╝ ┐_▓Á╝ ? _Á_▓Á╝¢ ¼©╣¢ ╝Á¢Á/╝│© ┴╣%% Á┬║/┤ ?┐╝ ,?┴%Á┤ÀÁ ? ¥©╣¢ ╣_║?╝¥/¥ ╝ÁÀ╣? ? ¥©Á ┴?╝%┤ /┤└/│Á ¥©Á ¥╝/╣╣À ? / `?┐À ¢?│╣/% ¢│╣Á¥╣¢¥ /┤ ║╝?└╣┤Á Á┴ ,?┴%Á┤ÀÁ /▓?┐¥ │©/ÀÁ¢ ╣ ╝/│Á /¢ / ?╝À/╣:╣À ║╝╣│╣║%Á ╣ í╝/:╣%╣/ ¢?│╣Á¥`