Metal Complex Activation of Dioxygen

这个生物无机、无机和有机金属化学项目的奖项支持加州大学洛杉矶分校琼·s·瓦伦丁博士实验室的研究。要进行的研究包括有益和有毒的金属催化的双氧、超氧化物或过氧化物与有机底物的反应。原卟啉IX二甲酯的过氧铁配合物将作为模型化合物来阐明血红素含铁酶反应中涉及的中间体的性质。此外，铁神经黑色素类似物和铜金属硫蛋白与抗坏血酸和碳水化合物的反应将被研究，以研究这些化合物在氧化损伤中的作用。最后，改性星青花苷将用于模拟不确定形成的氧化催化剂的毒性反应性。生物学上重要的双氧及其代谢产物的反应往往是由金属酶催化的。所提出的研究将促进我们对金属催化氧化反应的机制的理解，这些反应可能涉及退行性疾病。

This award in the Bioinorganic, Inorganic and Organometallic Chemistry Program supports research in the laboratories of Dr. Joan S. Valentine at the University of California Los Angeles. The research to be performed involves the study of both beneficial and toxic metal-catalyzed reactions of dioxygen, superoxide or peroxide with organic substrates. The ferric peroxo complex of protoporphyrin IX dimethyl ester will be used as a model compound to elucidate the nature of intermediates involved in the reactions of heme iron-containing enzymes. Additionally, the reactions of iron-neuromelanin analogs and copper metallothioneins with ascorbate and carbohydrates will be examined to investigate the role of such compounds in oxidative damage. Finally, modified stellacyanin will be used to model the toxic reactivity of adventitiously formed oxidation catalysts. Biologically important reactions of dioxygen and its metabolites are often catalyzed by metalloenzymes. The proposed studies will advance our understanding of the mechanisms of metal-catalyzed oxygenation reactions suspected to be involved in degenerative diseases.