CAREER: Molecular Imprinting of Metal Oxides

拉森-9733756，内布拉斯加州大学林肯分校的古斯塔沃·拉森教授建议对过渡金属氧化物进行分子印迹，以赋予它们催化反应的分子识别能力。以二苯甲酰胺、α-苯基丙酸或N-苯甲酰基苯磺酰胺为模板剂在氧化锆和氧化钛表面进行印迹，并在需要H-离解活性时掺入金属铬。它们将通过重量法、红外光谱、醇的程序升温脱附以及用于测试手性选择性的探针反应(醇的脱水或氧化脱氢以及α-苯基丙酸的加氢)进行表征。确定了控制氧化锆印迹和在反应条件下稳定性的基本参数。这项研究将带来新的知识，有助于多相催化的一个关键领域：设计具有超高选择性的催化剂的能力。如果完全成功，这项工作将对精细化工行业产生影响，包括制药和农化过程。教育计划是一项全面的活动议程，可能会对内布拉斯加州的科学人力基础设施产生很大影响。教育计划的一部分是针对初中生和高中生，他们将接触到国家实验室和大学研究，因此可能会接触到国家实验室和大学研究，因此可能会越来越多地选择科学或工程职业。将作出一些努力，将国际学生纳入美国的教育体系，并加强国际合作。此外，教学计划还包括本科生的研究经验和课程开发。

Abstract - Larsen - 9733756 Prof. Gustavo Larsen of U. Nebraska-Lincoln proposes to molecularly imprint transition metal oxides in order to impart them molecular recognition capabilities for catalytic reactions. Zircona and titania surfaces will be imprinted by means of templating with dibenzamide, alpha-phenyl propionic acid, or N-benzoylbenzensulfonamide, and will be doped with Cr metal when H-dissociation activity is needed. They will be characterized gravimetrically, with infrared spectroscopy, by temperature-programmed desorption of alcohols, and by probe reactions to test for chiral selectivity (dehydration or oxidative dehydrogenation of alcohols, and hydrogenation of alpha-phenyl propionic acid). The fundamental parameters governing the imprinting of zirconia and the stability at reaction conditions wll be identified. The research will lead to new knowledge that helps a critical area of heterogeneous catalysis: the ability to design catalysts with ultra-high selectivity. If completely successful, the work will impact the fine chemical industries, including pharmaceutical and agrochemical processes. The educational plan is a comprehensive agenda of activities that may highly affect the scientific human infrastructure in the State of Nebraska. Part of the educational plan is targeted to junior and senior high-school students, who will be exposed to national laboratory and university research, and thus may will be exposed to national laboratory and university research, and thus may increasingly choose a career in science or engineering. Some effort will be applied to the insertion of international students in the American system and the enhancement of international collaborations. In addition, the teaching plan involves research experiences for undergraduate students as well as course development.