Incorporation of Fourier Transform Nuclear Magnetic Resonance Spectroscopy into the Undergraduate Chemistry Curriculum

化学系一直在重新设计其本科实验室，以便为学生提供接触现代化学仪器和当前实验室技术的机会。国防部正在采购一台200mhz傅里叶变换核磁共振（FT-NMR），以补充国防部现有的仪器。200兆赫的FT-NMR正在取代无法操作的90兆赫的CW-NMR，并使该部门的学生在化学培训期间经常接触核磁共振（NMR）技术。实验练习的顺序允许核磁共振教学尽早开始，并随着学生在化学课程中的进展而不断深入。微型实验已被纳入有机课程，以及合成和随后的分析当地发生的染料。产品的核磁共振分析对该实验室的教学价值有很大贡献。在物理化学实验室中，该仪器被用来确定平衡反应的速率常数，并说明海森堡不确定度关系随着谱线的展宽而明显。二维核磁共振也被引入，在仪器分析实验室，在测序短肽的背景下。该系还通过让学生确定10个碱基对DNA双链的序列，将这种光谱仪整合到生物化学和分子生物学实验室中。通过本系的实验课程，包括个人研究，让化学专业的学生接触核磁共振理论和应用，大大提高了他们的整体研究经验。

The Chemistry Department has been in the process of redesigning its undergraduate laboratories in order to provide students with exposure to modern chemical instrumentation and current laboratmry techniques. The department is acquiring a 200 MHz Fourier-transform nuclear-magnetic resonance (FT-NMR) that complements the department's existing instrumentation. The 200 MHz FT-NMR is replacing an inoperable 90 MHz CW-NMR, and enabling the department to expose students to nuclear-magnetic resonance (NMR) techniques frequently during their chemistry training. The sequence of laboratory exercises is allowing NMR instruction to begin early and proceed with increasing depth as students progress in the chemistry program. Microscale experiments have been incorporated into the organic curriculum, as well as the synthesis and subsequent analysis of a locally occurring dye. NMR analysis of products can contribute greatly to the instructional value of this laboratory. In the physical chemistry laboratory, the instrument is being used to determine rate constants for a reaction at equilibrium and illustrate Heisenberg uncertainty relationships evident as line broadening. Two-dimensional NMR is also being introduced, during the instrumental analysis laboratory, in the context of sequencing short peptides. The department is also integrating this spectrometer into the biochemistry and molecular biology laboratory by having students determine the sequence of a 10 base-pair DNA duplex. Exposing chemistry students to NMR theory and applications through the department's laboratory courses, including individual research, is greatly enhancing their overall research experience.