SBIR Phase I: Super-Fingerlings: The Development of Advanced Biotechnology, Genetic Manipulation and Animal Husbandry Techniques for Use in Aquaculture

这个小企业创新研究（SBIR）第一阶段项目将开发和利用先进的转基因基因工程方法来生产条纹鲈鱼鱼种，这些鱼种具有在美国常见的培养系统中有利于生产的性状，期望的性状包括加速生长和增强对细菌疾病的抵抗力。第一阶段将首先引入一个标记基因（外来遗传信息，可以很容易地识别），然后引入外来遗传物质，将赋予鱼所需的性状。如果成功，第一阶段将开发所需的辅助养殖和鱼类育种技术，以利用具有新性状的鱼种。关于美国水产养殖业的每一篇主要评论都指出，如果要扩大这一新兴产业，就迫切需要改进种子储备方法。在条纹鲈鱼中引入表达生长激素和抗菌分子的基因是一项复杂的任务，但回报可能是巨大的。条纹鲈鱼养殖在全球范围内呈爆炸式增长，尽管主要市场在美国，但外国产品很容易在一夜之间送到美国的任何地方。对这些方法的研究有望支持该行业应对日益激烈的全球竞争。

9760474 Carlberg This Small Business Innovation Research (SBIR) Phase I project will develop and utilize advanced transgenic genetic engineering methods to produce striped bass fingerlings with traits favorable production in culture systems common in the U.S. Desired traits include accelerated growth and increased resistance to bacterial disease. Phase I will first introduce a marker gene (foreign genetic information that can be readily identified) and then introduce foreign genetic material that will confer upon fish the desired traits. If this succeeds, Phase I will develop the required supporting culture and fish breeding technology to take advantage of fingerlings possessing the new traits. Every major review of U.S. aquaculture describes the critical need for improved seed stock methodologies if this new industry is to expand. The introduction of genes for expressing growth hormones and antimicrobial molecules in striped bass is a complex task, but the rewards could be significant. Striped bass farming has exploded around the world, and although the primary markets are in the U.S., foreign products are easily delivered fresh anywhere in the country overnight. Research on these methods is expected to buttress the industry against the rising global competition.