SBIR Phase I: A Fast Field Portable Gas Phase Explosives Detector

这个小企业创新研究第一阶段项目建议建立一个敏感、快速反应的便携式生物传感器的验证概念，该传感器可用于检测空气中未引爆的爆炸物。利用表面等离子体共振光谱（SPRS）技术检测固定化TNT抗体与气相TNT抗体之间的气相抗体-抗原反应，将根据本研究的结果研制出一种原型仪器。该研究包括两项研究：将特异性抗体电离到专门制备的金表面上，探索SPRS检测抗体-抗原反应的能力。研究还将评估检测的可检测性、速度和可重复性的限制。需要对未引爆炸药进行快速、可靠的现场便携式探测器。应用范围从侦测机场行李炸弹到侦测地雷和其他军用爆炸物。该奖项由小企业创新研究计划和刺激竞争研究实验计划（EPSCoR）支持。

This Small Business Innovation Research Phase I project proposes to establish proof concept for a sensitive, rapid response, portable biosensor that can be utilized in the detection of undetonated explosives in air. A prototype instrument will be derived from the results of this research based on the detection of the gas phase antibody-antigen reaction between immobilized TNT antibody and vapor phase TNT using Surface Plasmon Resonance Spectroscopy (SPRS). The research involves two studies: ionization of the specific antibody onto a specially prepared gold surface and exploration of the capabilities of SPRS to detect the antibody-antigen reaction. The studies will also assess the limits of delectability, speed, and reproducibility of detection. A need exists for fast, reliable, field portable detectors for undetonated explosives. Applications can range from the detection of luggage bombs at airports to the detection of land mines and other explosives for the military. This award is supported by the Small Business Innovation Research Program and the Experimental Program to Stimulate Competitive Research (EPSCoR).