SBIR Phase II: Electroplated Iridium Oxide Coatings for Functional Electrical Stimulation

*9800906 Twardoch这个小企业创新研究第二阶段项目的目标是开发一种电沉积氧化Ir的工艺，以在医用电极上生产保形涂层。由于其耐腐蚀性、低阻抗和高电荷注入能力，氧化Ir是功能电刺激(FES)电极的特例。目前制造这些涂层的方法对于许多复杂和温度敏感的设备来说是不可接受的，例如耳蜗植入物和神经袖带。通过电沉积，为各种FeS应用制造的电极可以用涂层“改造”，或者涂层过程可以集成到生产过程中。第一阶段的计划非常成功。开发了一种近中性、室温的水溶液镀液，用于在任何金属表面涂覆附着的、具有电活性的氧化Ir。第二阶段将发展对电沉积的控制，以在各种FeS衬底上产生在脉冲刺激条件下具有最大电荷接受度的电极涂层。计划与FES供应商和研究人员在不同领域进行合作，包括耳蜗术、膀胱术和皮质内假体。第三阶段将需要向FES社区提供涂层服务和许可。产品目标：1)用于治疗听力损失、大小便失禁、性功能障碍、肢体瘫痪和痉挛等功能损害的神经假体的商用医用电极；以及用于起搏器的去极化和腐蚀保护；2)涂覆电极的设备。***

*** 9800906 Twardoch This Small Business Innovation Research Phase II project has as its goal to develop a process for electrodeposition of iridium oxide to produce conformal coatings on medical electrodes. Iridium oxide is exceptional for functional electrical stimulation (FES) electrodes because of its corrosion resistance, low impedance, and high charge injection capacity. Current methods of fabricating these coatings are unacceptable for many of the complex and thermally sensitive devices such as cochlear implants and neural cuffs. With electrodeposition, manufactured electrodes for a variety of FES applications can be "retrofitted" with the coatings, or the coating procedure can be integrated into the production process. The Phase I program was extremely successful. A near-neutral, room temperature aqueous plating bath has been developed for coating any metal surface with adherent, electroactive iridium oxide. Phase II will develop the control of electrodeposition to produce electrode coatings with maximum charge acceptance under pulse stimulation conditions on a variety of FES substrates. Collaborations with FES vendors and researchers in diverse areas, including cochlear, bladder and intracortical prostheses are planned. Phase III will entail coating services and licensing to the FES community. Product targets: 1) Commercial medical electrodes for neural prosthesis for treatment of functional impairment such as hearing loss, incontinence, sexual dysfunction, limb paralysis, and spasficity; and for depolarization and corrosion protection in pacemakers 2) Equipment for coating electrodes. ***