U.S.-Czech Research on DNA Interactions of Polynuclear Platinum

INT 9805552法雷尔美国-位于里士满的弗吉尼亚联邦大学的Nicholas Farrell和布尔诺生物物理研究所的Viktor Brabec之间的捷克研究项目对双核和三核铂络合物诱导的DNA构象变化进行了详细的结构检查。 研究人员打算制备双核和三核复合物的位点特异性DNA加合物，并系统地研究它们的结构和构象序列。 结果有望产生一个三维的图片的结构的特定的DNA加合物，并提高我们的理解DNA拓扑结构的影响，其结合模式铂络合物和它们的识别特定的蛋白质。 如果成功的话，这些发现可能有助于改进一类新的抗肿瘤药物。这个生物化学方面的合作研究项目实现了通过使美国和中欧的领先专家联合收割机在共同感兴趣和能力强的领域结合互补的人才和集中研究资源来推进科学知识的计划目标。

INT 9805552FarrellThis U.S.-Czech research project between Nicholas Farrell of Virginia Commonwealth University, Richmond, and Viktor Brabec of Institute of Biophysics, Brno, features detailed structural examination of the conformational changes induced in DNA by dinuclear and trinuclear platinum complexes. The researchers intend to prepare site-specific DNA adducts of di- and trinuclear complexes and systematically examine their structure and conformational sequences. Results are expected to produce a three dimensional picture of the structures of specific DNA adducts and to improve our understanding of the effect of DNA topology on its binding modes to platinum complexes and their recognition by specific proteins. If successful, findings may be useful in refining a new class of antitumor agents.This cooperative research project in biochemistry fulfills the program objective of advancing scientific knowledge by enabling leading experts in the United States and Central Europe to combine complementary talents and pool research resources in areas of strong mutual interest and competence.