Purchase of a New 400 MHz Liquid Phase NMR Spectrometer

化学研究仪器和设施(CRIF)计划的这一奖项将帮助德克萨斯理工大学化学和生物化学系购买400 MHz液体核磁共振(核磁共振)光谱仪。该装置将加强以下领域的研究：(1)用喹酮海绵代谢物Puupehenone对抗原肽进行共价修饰，(2)生物活性物质P类似物的合成和固相结构，(3)用于识别离子客体的合成有机主体，(4)不对称反应催化剂和(5)紫杉醇衍生物的合成。核磁共振波谱是化学家用来解释分子结构的最有力的工具。它被用来识别未知物质，表征分子内原子的特定排列，并研究溶液中分子之间相互作用的动力学。对于正在进行前沿研究的化学家来说，获得最先进的核磁共振光谱是必不可少的。这些核磁共振研究的结果在聚合物、催化和生物学等领域都是有用的。

This award from the Chemistry Research Instrumentation and Facilities (CRIF) Program will assist the Department of Chemistry and Biochemistry at Texas Tech University to purchase a 400 MHz liquid phase nuclear magnetic resonance (NMR) spectrometer. This equipment will enhance research in a number of areas such as the following: (1) covalent modification of antigenic peptides by the quinonoid sponge metabolite puupehenone, (2) synthesis and solid solution phase structures of biologically active substance P analogs, (3) synthetic organic hosts for the recognition of ionic guests, (4) catalysts for asymmetric reactions and (5) the synthesis of taxol derivatives. Nuclear Magnetic Resonance (NMR) spectroscopy is the most powerful tool available to chemists for the elucidation of the structure of molecules. It is used to identify unknown substances, characterize specific arrangements of atoms within molecules, and to study the dynamics of interactions between molecules in solution. Access to state-of-the-art NMR spectrometry is essential to chemists who are carrying out frontier research. The results from these NMR studies are useful in the areas such as polymers, catalysis, and in biology.