Organic Chemistry: Multistep Synthesis, New Synthetic Methodology, Exploratory Chemistry

本研究的重点扩展到全面综合和方法发展。特定的分子靶点包括tnf - α拮抗剂维尼格罗、强效杀虫生物碱单叶碱、八环多萜类化合物八环壬戊二烯、植物激素前体3 -羟基-烯烯和强效甾体避孕药去索孕酮。新方法的研究课题包括烯醇酯的对映选择性相转移烷基化反应、手性超路易斯酸对映选择性合成催化剂的设计与应用、羰基对映选择性还原的新型杂氮硼烷催化剂、合成手性-锡基和-锂基甲醇的新工艺、介绍了利用片段偶联合成烯烃的立体定向新方法及其在阳离子-烯烃环化合成复杂多环结构中的应用。有了这个更新奖，有机和大分子化学项目支持哈佛大学化学和化学生物系的Elias J. Corey博士的研究。Corey教授将专注于开发复杂的、具有生物活性的有机化合物的多步骤合成途径，以及发现构建有机分子的新方法和通用方法。

The foci of this research extend to total synthesis and methodology development. Specific molecular targets include the TNF-alpha antagonist vinigrol, the potent insecticidal alkaloid haplophytine, the octacyclic polyterpenoid octacyclononaprenol, the plant hormone precursor 3alpha-hydroxy-ent-kaurene and the potent steroidal contraceptive agent desogestrel. Among the topics of study in new methodology are enantioselective catalytic phase transfer alkylation of enolates, design and application of chiral super Lewis acids as catalysts for enantioselective synthesis, new oxazaborolidine catalysts for the enantioselective reduction of carbonyl groups, a new process for the synthesis of chiral alpha-stannyl- and alpha-lithio-carbinols, and new stereospecific methods for the synthesis of olefins by fragment coupling and the application of theses products to the synthesis of complex polycyclic structures by cation-olefin cyclization. With this renewal award, the Organic and Macromolecular Chemistry Program is supporting the research of Dr. Elias J. Corey of the Department of Chemistry and Chemical Biology at Harvard University. Professor Corey will focus his work on the development of multistep synthetic pathways to complex, bioactive organic compounds and on the discovery of new and general methods for the construction of organic molecules.