Natural Products Chemistry of Marine Invertebrates

这项研究的重点是利用为研究共生关系而开发的新方法来调查声称其共生体起源的海洋天然产品的来源。除了正在进行的三项研究涉及海绵海绵、海绵中的吡哆吖啶生物碱和茉莉花胺外，还将开展六项相关研究，涉及可能对海洋生物和生物技术产生影响的特定代谢物或一般类别的化学品。进一步的海绵化学研究有望产生新的环肽和糖肽，其分子量在1500-2000 Da之间。射程。分子遗传学将被用来确定产生不同环肽的共生丝状细菌之间的关系。还将确定来自海洋无脊椎动物的新化学结构。有了这个续展奖，有机和高分子化学计划将支持加州大学圣地亚哥分校斯克里普斯海洋研究所海洋研究部的D·约翰·福克纳博士的研究。福克纳教授将对海洋无脊椎动物进行化学研究，这将为发现新的天然产品提供独特的机会，并调查它们在生态和进化中的作用。指导这项研究的一个基本假设是，次生代谢物对生产和/或使用次生代谢物的有机体的进化成功做出了贡献。这项研究将探索可能影响海洋生物、生态和生物技术的海洋天然产品化学领域。

The focus of this research is the investigation of the sources of marine natural products for which a symbiont origin has been claimed by use of novel methods developed for the study of symbiotic associations. In addition to three studies in progress that involve lithistid sponges, pyridoacridine alkaloids in sponges and jaspamine, six related studies will be carried out involving either specific metabolites or general classes of chemicals that were selected for potential impact on marine biology and biotechnology. Further chemical investigations of lithistid sponges are expected to yield new cyclic peptides and glycopeptides with molecular weights in the 1500-2000 Da. range. Molecular genetics will be used to determine the relationships between symbiotic filamentous bacteria that produce different cyclic peptides. Novel chemical structures from marine invertebrates will also be identified.With this renewal award, the Organic and Macromolecular Chemistry Program is supporting the research of Dr. D. John Faulkner of the Marine Research Division of the University of California, San Diego Scripps Institution of Oceanography. Professor Faulkner will carry out chemical studies of marine invertebrates that will provide unique opportunities to discover new natural products and to investigate their ecological and evolutionary roles. A basic hypothesis that guides this research is that secondary metabolites have contributed to the evolutionary success of the organisms that produce and/or use them. This research will probe areas of marine natural products chemistry that may impact marine biology, ecology and biotechnology.