The Synthesis of Bioactive Natural Products as a Driving Force for Discovery in Organic Chemistry
生物活性天然产物的合成作为有机化学发现的驱动力
基本信息
- 批准号:10596203
- 负责人:
- 金额:$ 58.6万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2022
- 资助国家:美国
- 起止时间:2022-04-01 至 2027-03-31
- 项目状态:未结题
- 来源:
- 关键词:AcylationAlkylationApplications GrantsBiologicalCarbonChemicalsChemistryComplexDevelopmentElementsGovernmentHumanHydrogenationIndustrializationInvestigationLaboratoriesMedicineMethodologyMethodsNatural ProductsOrganic ChemistryPreparationProcessPublic HealthReactionResearchRouteScienceStructureSynthesis ChemistryTechnologyTestingTransition Elementsarmbioactive natural productsdriving forcenew technologynovelprogramstool
项目摘要
Project Summary/Abstract:
The objective of this research program is to discover and develop new reaction
methodology en route to the synthesis of complex bioactive molecules. Our proposed
studies will focus on the investigation and optimization of technologies that enable the
synthesis of core structural and stereochemical subunits prevalent in many bioactive,
polycyclic natural products. The processes that we develop will find utility in the
synthesis of a wide variety of structures for which there are currently no efficient
synthetic roadmaps. Importantly, the methods presented in this application will be
useful outside of the contexts described herein and will arm practitioners of synthetic
chemistry (in academic, government, and industrial laboratories) with a new set of
important tools to access enantioenriched and functionally diverse chemical building
blocks for synthesis.
The research proposed in this grant application is focused on a) the development of
new stereoselective reactions that produce densely substituted building blocks for
synthesis, b) the development of transition metal catalyzed reactions for asymmetric
alkylation, acylation, and hydrogenation processes, c) the development of these novel
methods specifically for the preparation of building blocks containing all-carbon
quaternary stereocenters and arrays of stereocenters, and d) the implementation of these
new tactics in the syntheses of highly complex, bioactive natural products. These
molecules are not only important from a biological standpoint, they also serve as a
testing ground for our new technologies. As a consequence of this approach, we will
have access to a) novel, medicinally relevant structures, b) a general platform for their
synthesis, and c) new synthetic methodology that will impact a host of diverse
applications.
项目总结/文摘:
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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BRIAN M STOLTZ其他文献
BRIAN M STOLTZ的其他文献
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{{ truncateString('BRIAN M STOLTZ', 18)}}的其他基金
The Synthesis of Bioactive Natural Products as a Driving Force for Discovery in Organic Chemistry
生物活性天然产物的合成作为有机化学发现的驱动力
- 批准号:
10757281 - 财政年份:2022
- 资助金额:
$ 58.6万 - 项目类别:
The Synthesis of Bioactive Natural Products as a Driving Force for Discovery in Organic Chemistry
生物活性天然产物的合成作为有机化学发现的驱动力
- 批准号:
10799330 - 财政年份:2022
- 资助金额:
$ 58.6万 - 项目类别:
The Synthesis of Bioactive Natural Products as a Driving Force for Discovery in Organic Chemistry
生物活性天然产物的合成作为有机化学发现的驱动力
- 批准号:
10406108 - 财政年份:2022
- 资助金额:
$ 58.6万 - 项目类别:
The Synthesis of Bioactive Polycyclic Natural Products
生物活性多环天然产物的合成
- 批准号:
7459760 - 财政年份:2007
- 资助金额:
$ 58.6万 - 项目类别:
The Synthesis of Bioactive Polycyclic Natural Products
生物活性多环天然产物的合成
- 批准号:
7628979 - 财政年份:2007
- 资助金额:
$ 58.6万 - 项目类别:
The Synthesis of Bioactive Polycyclic Natural Products
生物活性多环天然产物的合成
- 批准号:
10063991 - 财政年份:2007
- 资助金额:
$ 58.6万 - 项目类别:
The Synthesis of Bioactive Polycyclic Natural Products
生物活性多环天然产物的合成
- 批准号:
9140046 - 财政年份:2007
- 资助金额:
$ 58.6万 - 项目类别:
The Synthesis of Bioactive Polycyclic Natural Products
生物活性多环天然产物的合成
- 批准号:
8183101 - 财政年份:2007
- 资助金额:
$ 58.6万 - 项目类别:
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