NSF/EPA TSE: Metabolic Engineering of Methylotrophic Bacteria for Conversion of Methanol to Higher Value-Added Products

本项目的目标是通过对甲基营养菌扭脱甲基杆菌AM 1的定向代谢工程，开发用于将甲醇转化为更高附加值产品的优化菌株。 有待检验的假设是，通过操纵甲醛的产生和消耗途径，可以优化能量代谢，并将碳通量导向特定的代谢分支。 该奖项是由美国国家科学基金会作为一个可持续发展的环境技术联合NSF/EPA计划的一部分。

The goal of this project is to develop an optimized strain for converting methanol into higher value added products by directed metabolic engineering of a methylotrophic bacterium, Methylobacterium extorquens AM1. The hypothesis to be tested is that energy metabolism can be optimized and carbon flux can be directed to specific metabolic branches by manipulating formaldehyde production and consuption pathways. This award ismade by NSF as part of the joint NSF/EPA Program on Technologiesfor a Sustainable Environment.