Integration of Optical Spectroscopy and Optical Coherence Tomography: Increased Contrast to Recognize Early Ovarian Cancers

本研究的目的是开发新的知识和技术，整合光学相干层析成像（OCT）和光谱学的优势。目的是使高对比度，分子特异性的光学成像早期肿瘤上皮组织。这将需要开发新的生物学模型，以便对这些概念进行严格的测试。此外，从这些模型中获得的知识将用于开发光学系统，以解决卵巢癌的临床重要问题。这些目标的完成将需要：(1)在光散射的细胞基础以及如何使用外部介质进行操作的理解方面取得根本性的进展，(2)同步成像和光谱学的技术发展，以及(3)分子造影剂和测试工具的开发

9872829Richards-KortumThe objective of this research is to develop new knowledge and technologies which integrate the advantages of optical coherence tomographic (OCT) imaging and optical spectroscopy. The aim is to enable high-contrast, molecular-specific optical imaging of early tumors in epithelial tissues. This will require the development of new biological models to allow rigorous testing of these concepts. Also, the knowledge gained from these models will be used to develop an optical system to address the clinically significant problem of ovarian cancer. The completion of these objectives will require: (1) fundamental advances in the understanding of the cellular basis of light scattering and how it can be manipulated with extrinsic agents, (2) technology development for simultaneous imaging and spectroscopy, and (3) development of molecular contrast agents and tools to test tools and developments.***