Interlocked Molecules Beyond Catenanes and Rotaxanes

这个超分子化学领域的研究项目的目标是合成越来越大和越来越复杂的连环烷和轮烷。该项目寻求采用热力学控制合成简单的含亚胺的轮烷和链烷作为原理证明，然后在各种几何形状的支架周围构建更复杂的连锁分子。超分子辅助将获得一个公认的识别基序-即铵离子/冠醚相互作用。通过这个奖项，有机和大分子化学项目支持加州大学洛杉矶分校的Fraser B. Stoddart教授的研究工作。斯托达特教授正在探索创造分子的方法，这些分子可以作为各种不同技术的机器。目前阶段的研究旨在建立基于控制要素的装配协议，这些要素是最后装配的组成部分。这种所谓的热力学控制利用基本的吸引力和排斥力来引导组件进入适当的位置。

This research project in the area of supramolecular chemistry targets the synthesis of catenanes and rotaxanes of increasing size and complexity. The project seeks to employ thermodynamically-controlled synthesis of simple imine-containing rotaxanes and catenanes as proof of principle, and then of more complex interlocked molecules constructed around scaffolds of various geometries. Supramolecular assistance will be gained from a well-established recognition motif -- namely that of the ammonium ion/crown ether interaction.With this Award, the Organic and Macromolecular Chemistry Program supports the research efforts of Professor Fraser B. Stoddart of the University of California Los Angeles. Professor Stoddart is exploring methods for the creation of molecules that can act as machines for a wide range of different technologies. The present stage of the research seeks to establish assembly protocols based on control elements that are constituent parts of the final assembly. This so-called thermodynamic control takes advantage of basic attractive and repulsive forces that guide the component parts of the assembly into the proper positions.