Atomic-Scale Engineering of Bioactive Organic Molecules on Surfaces

表面生物活性有机分子的原子尺度工程

• 批准号: DP240100464
• 负责人: Dr Peter Jacobson
• 金额: $ 23.13万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2024
• 资助国家: 澳大利亚
• 起止时间: 2024-01-01 至 2026-12-31
• 项目状态: 未结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP240100464
• 关键词: Atomic; Scale; Engineering; Bioactive; Organic

Advances in scanning probe microscopy (SPM) have enabled the precise engineering of matter at surfaces. The ability to image and track changes at surfaces is simply staggering, but the frontier of molecules with pharmaceutical and agrichemical importance remains unexplored. This interdisciplinary project aims to synthesise fundamental molecules and reveal molecular rearrangement pathways utilising SPM. Expected outcomes of this project include new methods to couple molecules otherwise unobtainable by traditional means and fundamental knowledge of molecular manipulation and chemical structure. This aims to provide significant benefits, such as the translation of new chemical principles to academic and industrial laboratories.

扫描探针显微镜（SPM）的进步使物质表面的精确工程成为可能。成像和跟踪表面变化的能力简直令人震惊，但具有药物和农业化学重要性的分子的前沿仍然未被探索。这个跨学科的项目旨在利用SPM合成基本分子并揭示分子重排途径。该项目的预期成果包括通过传统手段无法获得的分子偶联新方法以及分子操作和化学结构的基础知识。其目的是提供显著的益处，例如将新的化学原理转化为学术和工业实验室。