U.S. Korea Cooperative Science: Assessing the Function of Nek2

9910500 Wolgemuth该奖项支持哥伦比亚大学Debra J. Wolgemuth博士和韩国Seol国立大学Kunsoo Rhee博士之间为期2年的合作研究项目。 这项合作旨在探索人类NIMA样激酶Nek 2在生殖细胞和其他细胞类型发育过程中的功能。 研究工作的长期目标是阐明控制生殖系细胞有丝分裂和减数分裂的遗传程序，特别是考虑到这些过程的调节的进化保守性。这项合作建议概述了遗传和生化实验，开始确定Nek 2的作用，Nek 2是一种假定的哺乳动物的aspermart. tag_nimA同源物。 研究结果将有助于深入了解NIMA通路在哺乳动物减数分裂中的功能，为高等生物减数分裂的控制提供新的理解，并为细胞分裂过程的进化保守提供信息。韩国合作科学计划。 协作互动将有助于分享专门知识和资源。 该项目与美国的目标有关-韩国合作科学计划，旨在通过科学信息、思想、技能和技术的交流，以及通过在互利问题上的合作，提高美国和韩国科学家和工程师之间的合作水平。 韩国的参与得到了韩国科学与工程基金会（KOSEF）的支持。

9910500WolgemuthThis award supports a 2-year collaborative research project between Dr. Debra J. Wolgemuth, Columbia University and Dr. Kunsoo Rhee, Seol National University, Korea. The proposed collaboration aims to explore the function of a human NIMA-like kinase, Nek2 during development of germ cells and other cell types. The long-term goal of the research effort is to elucidate the genetic program controlling the mitotic and meiotic divisions of the germ line cells, with particular consideration of the evolutionary conservation of the regulation of these processes.This collaborative proposal outlines genetic and biochemical experiments to begin to determine the role of Nek2, a putative mammalian homologue of aspergillus nimA. The results can provide insight into the function of the NIMA pathway in mammalian meiosis, providing new understanding of the control of meiosis in higher organisms as well as information on the evolutionary conservation of cell division processes.This project will be performed in conjunction with Dr. Kunsoo Rhee at Korea under the U.S.-Korea Cooperative Science Program. The collaborative interaction will provide for sharing of expertise and resources. This project is relevant to the objectives of the U.S.-Korea Cooperative Science Program, which seeks to increase the level of cooperation between U.S. and Korean scientists and engineers through the exchange of scientific information, ideas, skills, and techniques and through collaboration on problems of mutual benefit. Korean participation is supported by the Korea Science and Engineering Foundation (KOSEF).