Introducing FT-NMR In The Undergraduate Curriculum

傅里叶变换核磁共振波谱（FT-NMR）是一种强大的仪器方法，化学家和生物化学家现在经常使用它来阐明各种大小大分子的结构。由于需要昂贵的仪器，这种技术在小型学院中并不总是得到充分的解决。传统的本科教材在将这一主题引入大二有机化学课程方面进展缓慢。为了让学生对傅里叶核磁共振有更充分的背景和了解，本建议的目标如下：(1)在大二有机化学、第一学期生物化学实验室、仪器分析实验室和法医学实验室的课程中，向学生介绍傅里叶核磁共振理论并提供动手仪器分析的机会。(2)通过为期两周的暑期讲座和迷你实验课程，向有才华的高中生介绍FT-NMR概念。(3)提高学生对FT-NMR作为结构分析的宝贵工具的兴趣和热情。为了帮助实现这些目标，学院购买了一个FT-NMR转换包，该包在实验室中提供了一个低成本的替代FT-NMR单元，并将磁铁用于已经拥有的Varian EM-390 NMR系统。该装置不需要昂贵的维护合同，也不需要液氦和液氮的持续成本来维持过冷磁铁。学生和教师都可以用最少的时间和训练获得自己的光谱。一步实验设置指南允许FT-NMR系统在短时间内启动和运行。各种各样的实验室实验和应用从文献改编和介绍到上述课程。因此，学生能够理解FT-NMR的基本理论，收集和处理自己的光谱，并解释光谱，从而识别给定有机分子的部分或完整结构。

Chemistry (12)Fourier transform nuclear magnetic resonance spectroscopy (FT-NMR) is a powerful instrumental method that chemists and biochemists now use routinely for elucidating the structures of various small and large macromolecules. This technique is not always adequately addressed in small colleges because of the expensive instrumentation required. Traditional undergraduate textbooks have been slow to introduce this topic into the sophomore level organic chemistry course. In order to provide students with a more adequate background and understanding of FT-NMR, the following objectives have been identified for this proposal: (1) Introduce FT-NMR theory and offer hands-on instrumental analysis to students in the courses of sophomore organic chemistry, first semester biochemistry laboratory, instrumental analysis laboratory, and forensic science laboratory. (2) Introduce FT-NMR concepts to talented high school students in a two-week summer lecture and lab-minicourse. (3) Increase the interest and enthusiasm of students for FT-NMR as a valuable tool for structure analysis. To help meet these objectives the college has purchased an FT-NMR conversion package which provides a low-cost alternative FT-NMR unit in the laboratory and utilizes the magnet for an already owned Varian EM-390 NMR system. This unit does not require an expensive maintenance contract or the ongoing cost of liquid helium and liquid nitrogen to maintain a supercooled magnet. Both students and faculty are able to obtain their own spectra with a minimum amount of time and training. One-step experimental setup guides allow the FT-NMR system to be up and running in a short period of time. A variety of laboratory experiments and applications from literature are being adapted and introduced into the above courses. As a result, students are able to understand the basic theory of FT-NMR, to collect and process their own spectra, and to interpret the spectra, thereby identifying the partial or complete structure of a given organic molecule.