SBIR Phase I: Advanced Positron Annihilation Mass Spectrometer

这个小型企业创新研究第一阶段项目将确定开发一种基于正电子湮没的大大改进的质谱计的可行性。该项目是基于使用缓冲气体从潘宁陷阱的放射源积累正电子的技术的最新发展。先进的正电子质谱仪将使用正电子精确控制复杂分子的电离和碎裂。第一阶段的技术目标是：(1)组装一个研究生物分子正电子电离质谱学的实验；(2)进行实验，将这些分子的正电子电离性能与目前用于质谱学的离子源进行比较；(3)进行第二阶段实验室原型系统的概念设计。第一阶段可行性实验将在加州大学圣地亚哥分校的正电子陷阱上进行。如果成功，该项目将为在第二阶段演示质谱仪的实验室原型提供基础。第一阶段和第二阶段将为第三阶段的新技术商业化奠定基础。该项目涉及1999年具有国家重要性的关键技术--生物技术。

This Small Business Innovation Research Phase I project will establish the feasibility of developing a greatly improved mass spectrometer based on the annihilation of positrons. The project is based on the latest developments in techniques to accumulate positrons from a radioactive source in Penning traps using a buffer gas. The Advanced Positron Mass Spectrometer will use positrons to control precisely the ionization and fragmentation of complex molecules. The technical objectives of Phase I are to: (1) assemble an experimentto investigate positron ionization mass spectrometry of biomolecules; (2) perform experiments to compare the performance of positron ionization of these molecules with currently used ion sources for mass spectrometry; and (3) carry out the conceptual design of a laboratory prototype system for Phase II. The Phase I feasibility experiments will be performed on the positron trap at the University of California, San Diego. If successful, this project will provide the basis for demonstration of a laboratory prototype of themass spectrometer in Phase II. Phase I and II will provide the foundation for commercializing the new technology in Phase III. This project addresses a 1999 critical technology of national importance, biotechnology.