Integrating FT-NMR Spectroscopy Across the Undergraduate Curriculum

由于FT-NMR光谱学已成为化学结构和机制的阐明的一个强大的，常规的工具，它应该是任何本科化学课程的重要组成部分。为了有效地竞争，学生必须获得这种宝贵技术的实践经验。多核高场FT NMR光谱仪对我们机构为科学专业提供的几乎每一门化学课程都产生了积极的影响。在我们的实验室引进的新实验包括：在羧酸的结构异构;定量分析胺/醇混合物的19 F NMR没有事先分离;微观质子化平衡的多元分子; T1的探测二氢与氢化物离子键合在铱配合物;立体异构在三（三氟乙酰丙酮）铝（III）配合物。我们正在使用一个系统的，渐进的方法，我们的学生的四年NMR光谱学的学习经验。在第一年的实验中，学生使用实验的克当量结合他们对酸的1 H NMR光谱的解释来识别一种未知的简单羧酸。通过比较实验结果，引导学生认识同分异构体之间的差异。这种基于NMR光谱的分子水平实验探索为初学者提供了一个令人耳目一新的现代化学介绍，并希望吸引有才华的学生选择进一步的化学研究。NMR到本科教学/研究实验室的整合显著借鉴了两个NSF项目的经验：NSF-DUE 9351303，NMR在综合先进实验室;和RUI-CIP，收购高场NMR光谱仪。

Because FT-NMR spectroscopy has become a powerful, routine tool for the elucidation of structure and mechanism in chemistry, it should be a critical component of any undergraduate chemistry program. In order to compete effectively it is imperative that students receive hands-on experience with this valuable technique. A multinuclear high field FT NMR spectrometer is having a vitalizing impact on virtually every chemistry course offered for science majors at our institution. New experiments introduced in our laboratories include: structural isomerism in carboxylic acids; quantitative analysis of amine/alcohols mixtures by 19 F NMR without prior separation; microscopic protonation equilibria of polybasic molecules; T1 s to probe dihydrogen vs. hydride ion bonding in iridium complexes; stereoisomerism in tris(trifluorocetylacetonate) aluminum(III) complexes. We are using a systematic, graduated approach to our students' four-year NMR spectroscopy learning experience. In the first year laboratory, students identify a simple carboxylic acid unknown using an experimental Gram Equivalent Weight in conjunction with their interpretation of the acid's 1 H NMR spectrum. Students are guided to see the differences between isomeric compounds by comparing their experimental results. This NMR spectroscopy-based, experimental excursion into the molecular level gives beginning students a refreshingly modern introduction to chemistry and hopefully attracts talented students to elect further studies in chemistry. The integration of NMR into the undergraduate teaching/ research laboratory draws significantly upon the experience of two NSF projects: NSF-DUE 9351303, NMR in an Integrated Advanced Laboratory; and an RUI-CIP, Acquisition of a High Field NMR Spectrometer.