A Web-based Relational Database for Thermodynamic and Structure Data on Lipids

项目摘要DBI 9981990卡弗里俄亥俄州立大学基于网络的脂质热力学和结构数据的关系数据库选择性透膜是活细胞的基本特征。膜是一个双分子脂膜，膜内和膜上分布着蛋白质和其他分子。脂质的介晶性，或液晶性，允许膜定位在双层稳定性的边缘，从而调节膜的功能。在过去的三十年里，生物化学和生物物理界对生物和合成脂质的介晶性质的兴趣有了极大的增长。因此，存在着关于脂相行为的丰富信息，其中大部分散布在整个文献中。这项提议的目的是提供对这些数据、脂类分子结构和不断更新的关系数据库中的适当文献的随时网上访问，并提供一种在网上提交和分析数据的手段。这些数据有两种形式。第一种是指不同水化状态下的脂类的相变类型、温度和热焓。第二种是脂类混溶，用图形表示亚压和等温相图。该项目是跨学科的，因为它结合了一名研究脂质和膜结构生物学的生物化学家和一名计算机科学家与数据库专家的努力。网址：http://www.lipidat.chemistry.ohio-state.edu

Project AbstractDBI 9981990 Caffrey Ohio State University A web-based Relational Database for Thermodynamic and Structure Data on LipidsSelectively permeable membranes are an essential feature of living cells. The membrane is a bimolecular lipid leaflet in and on which are situated proteins and other molecules. Lipid mesomorphism, or liquid crystallinity, allows for the positioning of the membrane on the verge of bilayer stability thereby modulatingmembrane function. Interest in the mesomorphic properties of biological and synthetic lipids within the biochemistry and biophysics communities has grown enormously in the past three decades. As a result, there exists a wealth of information on lipid phase behavior, much of which is scattered throughout theliterature. The objective of this proposal is to provide ready web access to these data, to lipid molecular structures and to the appropriate literature in a continuously updated relational database and a means for data submission and analysis over the web. The data come in two forms. The first refers to phase transition types, temperatures and enthalpies for lipids in different hydration states. The second concerns lipid miscibility represented graphically asisobaric and isothermal phase diagrams. The project is cross-disciplinary in that it combines the efforts of a biochemist working on lipids and membrane structural biology and a computer scientist with database expertise.URL: http://www.lipidat.chemistry.ohio-state.edu