Feedback Control of Bifurcations in Small Pieces of Rapidly-paced Cardiac Muscle

这个项目的目标是开发策略，用于控制心肌的动力学使用偶尔的，小的扰动。 本工作采用了一个简单的实验台，由一小块连续起搏的牛蛙心室肌组成。 该计划的第一阶段将致力于确定快速起搏组织的动力学。 对组织的稳态和恢复特性以及组织对额外电刺激的响应的实验观察将与快速起搏组织的基于离子的数学模型的预测进行比较。 该计划的第二阶段涉及开发用于稳定（不稳定）起搏肌肉的不稳定（稳定）状态的方法，并将其应用于试验台。 该奖项由数学和物理科学局物理处和工程局生物医学工程和研究援助残疾人方案共同资助。

The goal of this project is to develop strategies for controlling the dynamics of cardiac muscle using occasional, small perturbations. A simple test-bed, consisting of a small piece of periodically-paced bullfrog ventricle myocardium, is used in the work. The first phase of the program will be devoted to determining the dynamics of the rapidly-paced tissue. Experimental observations on the steady-state and restitution properties of the tissue, as well as the response of the tissue to extra electrical stimuli, will be compared to the predictions of an ionic-based mathematical model of the rapidly-paced tissue. The second phase of the program involves developing methods for stabilizing (destabilizing) the unstable (stable) states of the periodically-paced muscle and applying them to the test-bed. This award is jointly funded by the Division of Physics in the Mathematical and Physical Sciences Directorate and the Biomedical Engineering and Research to Aid Persons with Disabilities Program in the Directorate for Engineering.