SBIR Phase II: Advanced Micro-Pixelized Scintillator for Structural Biology

这个小型企业创新研究第二阶段项目的目标是开发一种用于大分子结晶学的新型数字X射线探测器。该探测器基于新一代微像素化闪烁体，光学耦合到大面积数字读出阵列。微像素化闪烁体将提供非常高的灵敏度、空间分辨率和信噪比的独特组合，从而产生出色的点扩展函数(PSF)，从而提高测量的布拉格峰值数据的质量。当与大面积数字光学探测器集成时，它将允许以相对较低的成本实现宽动态范围和显著增强的吞吐量。除了结构生物学应用外，建议的探测器还将在使用高分辨率X射线成像的仪器中得到广泛使用。

This Small Business Innovation Research Phase II project is aimed at developing a novel digital x-ray detector for macromolecular crystallography. This detector is based on a new generation micro-pixelized scintillator optically coupled to a large area digital readout array. The micro-pixelized scintillator will provide a unique combination of very high sensitivity, spatial resolution, and signal to noise ratios resulting in excellent point spread function (PSF), thus improving the quality of the measured Bragg peak data.When integrated with a large area digital optical detector it will allow a wide dynamic range and substantially enhanced throughput at relatively low costs. In addition to the structural biology application, the proposed detector would find widespread use in instrumentation wherever high-resolution x-ray imaging is used.