CAREER: Metathesis Strategies to Diverse Sulfur- and Phosphorus-Based Oligomers

这项研究的重点是开发开环歧化聚合(ROMP)策略，以获得结构不同的含有硫基和磷基官能团的聚合物基元。重点将放在含有降冰片烯骨架的不对称单体单元的设计和合成上。使用ROMP方法将制备基于磺胺的寡肽、含有C2对称口袋的磺胺支架、聚合核酸支架和聚合脂质支架。这些不同的聚合物可能作为新型的药物制剂、不对称催化中的配体、人工脂质支架和DNA/RNA反义剂。该项目的教育部分强调对本科生的研究生指导，一个强有力的本科生辅导计划，多媒体实验室前准备和讲座演示，以及高中活动。有了这个职业奖项，有机和高分子化学计划正在支持堪萨斯大学化学系的保罗·R·汉森博士的研究和教育活动。汉森教授将把他的研究重点放在开发与药物相关的硫基和磷基齐聚物上。教育活动的重点包括辅导、辅导和本科课程发展。

The focus of this research is the development of ring-opening metathesis polymerization (ROMP) strategies to structurally diverse polymeric motifs that contain sulfur- and phosphorus-based functional groups. Emphasis will be placed on the design and synthesis of asymmetric monomeric units containing norbornene skeletons. Sulfonamide-based oligopeptides, sulfamide scaffolds containing C2-symmetric pockets, polymeric nucleic acid scaffolds and polymeric lipid scaffolds will be prepared using the ROMP methodology. These diverse polymers can potentially serve as novel pharmaceutical agents, ligands in asymmetric catalysis, artificial lipid scaffolds and DNA/RNA antisense agents. The educational portion of the project stresses graduate student mentoring of undergraduates, a vigorous undergraduate tutoring program, multi-media pre-laboratory preparation and lecture presentation, and high school outreach.With this CAREER award, the Organic and Macromolecular Chemistry Program is supporting the research and educational activities of Dr. Paul R. Hanson of the Department of Chemistry at the University of Kansas. Professor Hanson will focus his research on the development of pharmaceutically relevant sulfur- and phosphorus-based oligomers. The foci of the educational activities involve mentoring, tutoring and undergraduate course development.