Career: Quantitative Studies of Weak Interactions in Aqueous Solution: Anion Binding by Cationic Cyclodextrins

这个项目的目标是将研究和教育活动结合起来。研究活动包括确定一些生物上重要的离子对相互作用的热力学结合参数，这些相互作用涉及到氨基和胍基。这些测定将在水溶液中进行，使用一系列阳离子环糊精衍生物和适当的阴离子客体。这些研究使用的方法包括滴定量热法、核磁共振波谱和分子模型。有了这个奖项，有机化学和高分子化学计划支持马里兰大学巴尔的摩县分校的保罗·J·史密斯教授的研究和教育活动。史密斯教授将把研究和教育结合起来，让学生参与化学和生物之间的化学问题的研究。探索生物重要离子结合的研究确实将在生物化学和分子设计中产生重要的影响。

This project has as its goal the integration of research and educational activities. The research activities involve the determination of thermodynamic binding parameters for a number of biologically important ion-pairing interactions involving ammonium and guanidinium groups. These determinations will be made in aqueous solution using a series of cationic cyclodextrin derivatives and appropriate anionic guests. Methods employed for these studies will include titration calorimetry, NMR spectroscopy and molecular modeling.With this Award, the Organic and Macromolecular Chemistry Program supports the research and educational activities of Professor Paul J. Smith of the University of Maryland Baltimore County. Professor Smith will integrate research and education by involving students in the study of chemical problems that are at the interface between chemistry and biology. The research exploring the binding of biologically important ions will indeed have important ramifications in biochemistry and in molecular design.