Symposium on Subtypes of Muscarinic Receptors: Conference Grant: October 31- November 4, 2000; Houston, TX

9988690 Levine R这个研讨会于1983年首次提出，讨论的是影响某些重要身体功能的药物的作用，这些功能调节维持和生长。药物和内源性生理化学物质通过与具有重要功能的大分子组织成分--受体相互作用来减少它们的影响。这里特别感兴趣的受体是那些对内源性化学物质乙酰胆碱和蘑菇毒药毒蝇碱产生反应的受体。这些所谓的M受体分布在体内的许多部位，它们的激活或阻断可导致心率改变、唾液和胃肠道分泌物的刺激或阻塞，以及细支气管收缩等。较老的药物，如阿托品，与毒碱受体相互作用，在许多部位产生非选择性的影响。然而，研究的结果是，不同类型的M受体-亚型的概念成为现实，现在已经开发出许多药物，它们选择性地作用于某些M受体，而不作用于另一些受体，以产生预期的效果和较少的副作用。作为对M受体的基础研究的结果，新的选择性药物可用于治疗泌尿生殖系统和胃肠道问题、心血管和肺部疾病，并且M受体在阿尔茨海默病、精神分裂症和青光眼中的作用正在得到澄清。

9988690Levine R This symposium, first presented in 1983, deals with the action of drugs that affect some vital body functions regulating maintenance and growth. Drugs and endogenous physiologic chemicals reduce their effects by interacting with a macromolecular tissue constituent of functional significance, the receptor. The particular receptors of interest here are those that respond to the endogneous chemical, acetylecholine, and to the mushroom poison, muscarine. These so-called muscarinic receptors are located at many sites in the body and their activation or blockade can lead to changes in heart rate, stimulation or blockage of salivary and gastro-intestinal secretions, bronchiolar constriction among others. Older drugs, such as atropine, which interact with the muscarinic receptors produce effects non-selectively at many sites. However, as a result of research, the concept of different types of the muscarinic receptor-subtypes became a reality, and now many agents have been developed that act selectively at some muscarinic receptors and not at others, to produce the desired effects and fewer side-effects. As a result of basic research on muscarinic receptors, new selective agents are available for treatment of genito-urinary and gastrointestinal problems, cardiovasular and pulmonary diseases, and the role of muscarinic receptors in Alzheimer's diseas, schizophrenia and glaucoma is being clarified.