US-Turkey Cooperative Research: Bioactive Turkish Plant Constituents

0002071 Kingston描述：该奖项旨在支持弗吉尼亚州布莱克斯堡的弗吉尼亚理工学院和州立大学（VPI SU）化学系的大卫金斯顿博士和土耳其Gebze-Kocaeli的TUBITAK-Marmara研究中心化学系的Gulacti Topcu博士的合作。 这两位科学家计划从土耳其植物中分离和解析生物活性天然产物，特别是唇形科和菊科植物。 植物采集和提取将在土耳其进行。 使用基于酵母的生物测定进行的化合物分离最初将在VPI SU进行，并将随着项目的进展转移到TUBITAK-MRC。 结构解析将在两个地点进行。范围：该项目将支持两个国家的合格科学家的合作，并提供互补的能力和资源。 美国PI是几个合作药物发现项目的主要研究者。 土耳其拥有丰富的植物群，其中有许多特有物种，在民间医药中使用药用植物的历史悠久;然而，迄今为止的研究主要集中在经典的植物化学上，而不是生物活性成分的分离。这项拟议的研究将促进发现用于治疗癌症和真菌疾病的潜在药物，从而促进对天然产物和药物化学的认识和理解。 所选择的检测方法已被证明在学术和工业药物发现计划中是有效的，并且将很容易适应土耳其合作者的实验室使用。 拟议的计划包括使用生物测定和生物测定指导的分馏方面的大量培训内容，这将对研究和教学活动产生重大影响，并将确保这种高效的药物发现方法在土耳其得到推广和扩大。 该项目将通过提供土耳其丰富的植物群来加强PI的计划，也将使年轻的美国人受益。S.研究人员在他的小组中学习，让他们接触到富有成效的国际合作。该项目非常符合国际方案司鼓励在重要科学问题的研究方面进行互利合作的目标。

0002071KingstonDescription: This award is to support the collaboration of Dr. David Kingston, Department of Chemistry, Virginia Polytechnic Institute and State University (VPI&SU), Blacksburg, Virginia and Dr. Gulacti Topcu, Department of Chemistry, TUBITAK-Marmara Research Center, Gebze-Kocaeli, Turkey. The two scientists plan to work on the isolation and structure elucidation of bioactive natural products from Turkish plants, especially those of Labiatae and Compositae families. Plant collection and extraction will be carried out in Turkey. Compound isolation using yeast-based bioassays will initially be carried out at VPI&SU, and will be transferred to TUBITAK-MRC as the project progresses. Structure elucidation will be done at both locations.Scope: This project will support collaboration by qualified scientists in two countries with complimentary capabilities and resources. The US PI is a lead investigator in several collaborative drug discovery programs. Turkey has a rich flora with many endemic species, and has a long history of the use of medicinal plants in folk medicine; however, studies to date have focused on classical phytochemistry, as opposed to the isolation of bioactive constituents. The proposed study should advance the discovery of potential agents for the treatment of cancer and fungal diseases, with consequent advancement of knowledge and understanding in natural products and medicinal chemistry. The assays selected have proved to be effective in both academic and industrial drug discovery programs, and will be easily adapted to use in the laboratories of the Turkish collaborators. The proposed program includes a substantial training component in terms of use of the bioassays and bioassay-guided fractionation which will have a significant impact on the research and teaching activities, and will ensure that this highly effective approach to drug discovery will be promoted and expanded in Turkey. The project will strengthen the PI's program by providing access to the rich flora of Turkey, and will also benefit young U. S. investigators studying in his group through exposing them to productive international collaboration. The project fits well with the objective of the Division of International Programs for encouraging mutually beneficial collaboration on research in important scientific problems.