Biocompatible MEMS

该提案的重点是开发一种使MEMS设备与生物流体兼容的通用技术。其具体目标是使用表面改性和分析策略来了解在流动和静态条件下蛋白质与改性和未改性设备表面的相互作用，并最终能够使用于MEMS制造的任何材料具有生物兼容性。我们将研究不同电荷的蛋白质在不同通道几何形状和不同流速的特定表面上的吸附。我们不仅将研究抵抗蛋白质吸附的表面修饰，还将研究阻碍变性的修饰，因为抵抗蛋白质并不等同于防止蛋白质变性。最终目标将是将一种蛋白质(S)加入到一个稳定的层中，以防止变性和蛋白质积聚，这是模仿毛细管系统的。这项工作的应用跨越了科学和技术的范围，并可能导致工业部门处理生物兼容性问题的方式发生根本性变化。它还为多学科领域的学生和博士后提供教育培训。

The proposal is focused on developing an enabling generic technology to make MEMS devices compatible with biological fluids. The specific goal is to use surface modification and analysis strategies to understand protein interactions with the surfaces of modified and unmodified devices under flow and static conditions, and to be able to eventually make any material used for MEMS fabrication biocompatible. We will investigate the adsorption of differently charged proteins on specific surfaces in a variety of channel geometries and at different flow rates. We will examine not only surface modifications that resist protein adsorption, but also modifications that impede denaturization, as protein resistance is not the same as prevention of protein denaturization. The ultimate goal will be the eventual incorporation of a protein(s) in a stable layer that prevents denaturization and protein buildup modeled on capillary systems. The applications of this work span the range of science and technology, and could cause a fundamental change in how the industrial sector deals with the issue of biocompatibility. It also provides educational training for students and postdocs in a multidisciplinary area.