Physiological significance of transient receptor potential (TRPC3) ion channels in the cochlea
Physiological significance of transient receptor potential (TRPC3) ion channels in the cochlea
批准号:
DP1097202
负责人:
Prof Gary Housley
金额:
$19.49万
依托单位国家:
澳大利亚
项目类别:
Discovery Projects
财政年份:
2010
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2010-01-01 至 2015-12-31
中文摘要
该项目旨在发现瞬时受体电位(TRPC3)离子通道在耳蜗中的功能。最近的研究表明,这些由感觉细胞和神经细胞表达的蛋白是调节声音传导和神经传递的关键因素。这项工作将提供的关于听觉生理过程的新知识,将极大地有利于国内和国际的转化研究,这些研究旨在开发控制我们感官灵敏度的系统,开发生物传感器,与神经网络相互作用以及开发神经假体。该项目的国际合作者促进了新模式、技术和研究培训机会的发展。
英文摘要
The project seeks to discover the function of transient receptor potential (TRPC3) ion channels in the cochlea. Recent studies have suggested that these proteins, which are expressed by the sensory and neural cells, are key elements regulating sound transduction and neurotransmission. The new knowledge about the physiological processes underlying hearing that this work will provide, will significantly benefit national and international translational research that seeks to develop systems for controlling the sensitivity of our senses, developing biosensors, interacting with neural networks and developing neural prostheses. International collaborators in this project have enabled development of new models, technology and research training opportunities.
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