POWRE: Enzyme-Substrate Interactions Mediated by Vitamin B6

这个POWRE奖是为布兰代斯大学的PI提供的为期15个月的休假，与Dagmar Ringe教授的小组一起研究使用磷酸吡哆醛（维生素B6）作为辅助因子的酶系统。将建立酶-底物相互作用的量子力学-分子力学模型，并将其应用于维生素b6依赖性酶丙氨酸消旋酶和d -氨基酸转氨酶。该项目将使PI扩展她在生物化学和生物医学领域的知识，并在这些领域制定研究计划。该项目还旨在加强我们对酶作为催化剂如何发挥作用的理解。

OndrechenThis POWRE award is for a 15 month sabbatical for the PI at Brandeis University, working with Professor Dagmar Ringe's group on enzymatic systems that use pyridoxal phosphate (Vitamin B6) as a cofactor. A quantum mechanical-molecular mechanical model for enzyme-substrate interactions will be developed and applied to the vitamin B6-dependent enzymes alanine racemase and D-amino acid aminotransferase. This project will enable the PI to expand her knowledge in the biochemical and biomedical areas and develop a research program in these areas. The project is also designed to enhance our understanding of how enzymes perform their functions as catalysts.