The Chemistry of Fungal Antagonism and Defense

本研究的重点是研究在其他真菌的基质和多孔中定植的分枝寄生/真菌真菌。从乔治亚州南部和佛罗里达州北部的亚热带纬度获得的殖民者将增加从伊利诺伊州收集的样本中发现的生物多样性。研究了该菌群分离物对黄曲霉、黄萎病镰刀菌和重要农业昆虫褐夜蛾的抑菌活性。该项目的结果将有助于确定生态学原理是否可以作为发现新的和潜在的生物活性天然产品的有用指南。有机和大分子化学项目通过这一更新奖，支持了爱荷华大学化学系詹姆斯·b·格洛尔博士的研究。格洛尔博士与。美国农业部的唐纳德·t·威克洛（Donald T. Wicklow）和帕特里克·f·多德（Patrick F. Dowd）将把他的工作重点放在调查真菌入侵其他真菌的长期生存或“持久”的基质上。由于入侵可能涉及抗生素，真菌殖民者是抗真菌剂的潜在来源。这项工作对研究生来说是一个很好的训练基地，这项工作可能对制药和农业行业产生影响。

The focus of this research is the study of mycoparasitic/fungicolous fungi that colonize the stromata and polypores of other fungi. Colonists obtained from the southern, subtropical latitudes of southern Georgia and northern Florida will increase the biodiversity found in samples already collected from Illinois. Activity of isolates from the colonists against Aspergillus flavus, Fusarium verticillioides and the agriculturally important insect Spodoptera frugiperda will be tested. The results of the project will help to determine whether an ecological rationale can be useful as a guide to the discovery of new and potentially bioactive natural products.With this renewal award, the Organic and Macromolecular Chemistry Program is supporting the research of Dr. James B. Gloer of the Department of Chemistry at the University of Iowa. Dr. Gloer, in collaboration with Drs. Donald T. Wicklow and Patrick F. Dowd of the U.S. Department of Agriculture, will focus his work on investigating the the fungal invasion of long-lived or "persistent" stromata of other fungi. Since the invasion may involve antibiosis, the fungal colonists are a potential source of anti fungal agents. The work is an excellent training ground for graduate students and the work could have impact on the pharmaceutical and agricultural industries.