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MRI: Acquisition of a 400-MHz NMR Spectrometer with Nitrogen-Cooled Cryoprobe

MRI：使用氮气冷却冷冻探针采集 400 MHz NMR 波谱仪

基本信息

批准号：
2017828
负责人：
James Gloer
金额：
$ 43.12万
依托单位：
University of Iowa
依托单位国家：
美国
项目类别：
Standard Grant
财政年份：
2020
资助国家：
美国
起止时间：
2020-09-01 至 2023-08-31
项目状态：
已结题

来源：
https://www.nsf.gov/awardsearch/showAward?AWD_ID=2017828&HistoricalAwards=false
关键词：
MRI Acquisition 400 MHz NMR

项目摘要

This award is supported by the Major Research Instrumentation and the Chemistry Research Instrumentation programs. The University of Iowa is acquiring a 400 MHz nuclear magnetic resonance (NMR) spectrometer equipped with an inverse probe and a liquid-nitrogen cooled probe. The instrumentation supports Professors James Gloer, Leonard MacGillivray, Santhana Velupillai, Ned Bowden, Scott Daly and other colleagues. This spectrometer allows research in a variety of fields such as those that accelerate chemical reactions of significant economic importance, as well as permitting study of biologically relevant species. In general, NMR spectroscopy is one of the most powerful tools available to chemists for the elucidation of the structure of molecules. It is used to identify unknown substances, to characterize specific arrangements of atoms within molecules, and to study the dynamics of interactions between molecules in solution or in the solid state. Access to state-of-the-art NMR spectrometers is essential to chemists who are carrying out frontier research. This instrument is an integral part of teaching as well as research and research training of undergraduate students in chemistry and biochemistry at this institution and nearby institutions such as Augustana College, as well as Des Moines Area, Kirkwood, Indian Hills and Iowa Valley community colleges and some industrial partners.The award of the NMR spectrometer is aimed at enhancing research and education at all levels. It especially impacts the discovery of bioactive natural products and the analyses of environmental degradation products of steroids and other pharmaceuticals, as well as the studies on the role of hydrogen sulfide and its controlled release in agriculture using dithiophosphates. The instrumentation is also utilized for studying synthetic coordination chemistry and ligand design for carbon dioxide reduction and separation of actinides from lanthanides, and for the development of asymmetric synthetic strategies with applications to bioactive molecules relevant to human health. In addition, it provides information to understand the disposition and toxicity of environmental pollutants and their biotransformation products, and for the analyses of products formed from template-directed synthesis of complex molecules in the solid state. The NMR spectrometer is also used to develop catalytic transformations and strategies for bond activation and to study boron-mediated chemistry, exemplified by nitrene formation to generate amines through carbon–hydrogen functionalization processes.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

该奖项由主要研究仪器和化学研究仪器计划支持。爱荷华州大学正在购买一台400 MHz核磁共振（NMR）光谱仪，该光谱仪配备了一个反向探头和一个液氮冷却探头。该仪器支持James Gloer教授，伦纳德MacGillivray，Santhana Velupillai，Ned Bowden，Scott Daly和其他同事。该光谱仪可用于各种领域的研究，例如加速具有重要经济意义的化学反应，以及允许研究生物相关物种。一般来说，NMR光谱是化学家用来阐明分子结构的最有力的工具之一。它用于识别未知物质，表征分子内原子的特定排列，并研究溶液或固态分子之间相互作用的动力学。对于从事前沿研究的化学家来说，使用最先进的NMR光谱仪是必不可少的。该仪器是教学的一个组成部分，以及研究和研究培训的本科生在化学和生物化学在这个机构和附近的机构，如奥古斯塔纳学院，以及得梅因地区，柯克伍德，印第安山和爱荷华州谷社区学院和一些工业合作伙伴。该NMR光谱仪的奖项旨在加强各级研究和教育。它特别影响了生物活性天然产物的发现和类固醇和其他药物的环境降解产物的分析，以及对硫化氢的作用及其在农业中使用二硫代磷酸盐控制释放的研究。该仪器还用于研究合成配位化学和配体设计，用于二氧化碳还原和从镧系元素中分离锕系元素，以及用于开发应用于与人类健康相关的生物活性分子的不对称合成策略。此外，它还提供了信息，以了解环境污染物及其生物转化产物的处置和毒性，并分析从模板定向合成固态复杂分子形成的产物。NMR光谱仪还用于开发催化转化和键活化策略，以及研究硼介导的化学，例如通过碳氢官能化过程形成氮烯生成胺。该奖项反映了NSF的法定使命，并通过使用基金会的知识价值和更广泛的影响审查标准进行评估，被认为值得支持。

项目成果

期刊论文数量（16）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

The Influence of Phosphorus Substituents on the Structures and Solution Speciation of Trivalent Uranium and Lanthanide Phosphinodiboranates

磷取代基对三价铀和镧系膦二硼酸盐结构和溶液形态的影响

DOI：
10.1021/acs.inorgchem.3c02773
发表时间：
2023
期刊：
Inorganic Chemistry
影响因子：
4.6
作者：
Zgrabik, Joshua C.;Bhowmick, Rina;Eckstrom, Francesca D.;Harrison, A. Rayford;Fetrow, Taylor V.;Blake, Anastasia V.;Vlaisavljevich, Bess;Daly, Scott R.
通讯作者：
Daly, Scott R.

Polymerization of Primary Amines with Sulfur Monochloride to Yield Red Polymers with a Conjugated SN Backbone