MRI: Acquisition of a 400-MHz NMR Spectrometer with Nitrogen-Cooled Cryoprobe

该奖项由主要研究仪器项目和化学研究仪器项目支持。爱荷华大学正在购买一台400 MHz的核磁共振光谱仪，该光谱仪配备了一个反向探头和一个液氮冷却探头。该乐器支持詹姆斯·格洛尔教授、伦纳德·麦克吉利夫雷教授、桑塔娜·韦卢皮莱教授、内德·鲍登教授、斯科特·戴利教授和其他同事。这种光谱仪允许在各种领域进行研究，例如那些加速具有重大经济意义的化学反应的领域，以及允许研究具有生物相关性的物种。总体而言，核磁共振波谱是化学家用于阐明分子结构的最强大的工具之一。它被用来识别未知物质，表征分子中原子的特定排列，并研究分子在溶液或固体中相互作用的动力学。对于正在进行前沿研究的化学家来说，获得最先进的核磁共振光谱仪是必不可少的。该仪器是该机构以及附近的奥古斯塔纳学院、得梅因地区、柯克伍德、印第安山和爱荷华谷社区学院以及一些工业合作伙伴在化学和生物化学方面的本科生教学和研究培训不可或缺的一部分。核磁共振光谱仪的获奖旨在加强各级的研究和教育。它尤其影响到生物活性天然产物的发现和类固醇和其他药物的环境降解产物的分析，以及关于硫化氢在农业中的作用及其在使用二硫代磷酸盐的控制释放方面的研究。该仪器还被用于研究合成配位化学和配体设计，用于二氧化碳还原和从镧系元素中分离吖系元素，以及开发不对称合成策略，并应用于与人类健康相关的生物活性分子。此外，它还为了解环境污染物及其生物转化产物的分布和毒性，以及分析在固态下模板定向合成复杂分子所形成的产物提供了信息。核磁共振光谱仪还被用于开发催化转化和键活化策略，并研究硼介导的化学，例如通过碳氢官能化过程形成氮来生成胺。这一奖项反映了NSF的法定使命，并通过使用基金会的智力优势和更广泛的影响审查标准进行评估，被认为值得支持。

This award is supported by the Major Research Instrumentation and the Chemistry Research Instrumentation programs. The University of Iowa is acquiring a 400 MHz nuclear magnetic resonance (NMR) spectrometer equipped with an inverse probe and a liquid-nitrogen cooled probe. The instrumentation supports Professors James Gloer, Leonard MacGillivray, Santhana Velupillai, Ned Bowden, Scott Daly and other colleagues. This spectrometer allows research in a variety of fields such as those that accelerate chemical reactions of significant economic importance, as well as permitting study of biologically relevant species. In general, NMR spectroscopy is one of the most powerful tools available to chemists for the elucidation of the structure of molecules. It is used to identify unknown substances, to characterize specific arrangements of atoms within molecules, and to study the dynamics of interactions between molecules in solution or in the solid state. Access to state-of-the-art NMR spectrometers is essential to chemists who are carrying out frontier research. This instrument is an integral part of teaching as well as research and research training of undergraduate students in chemistry and biochemistry at this institution and nearby institutions such as Augustana College, as well as Des Moines Area, Kirkwood, Indian Hills and Iowa Valley community colleges and some industrial partners.The award of the NMR spectrometer is aimed at enhancing research and education at all levels. It especially impacts the discovery of bioactive natural products and the analyses of environmental degradation products of steroids and other pharmaceuticals, as well as the studies on the role of hydrogen sulfide and its controlled release in agriculture using dithiophosphates. The instrumentation is also utilized for studying synthetic coordination chemistry and ligand design for carbon dioxide reduction and separation of actinides from lanthanides, and for the development of asymmetric synthetic strategies with applications to bioactive molecules relevant to human health. In addition, it provides information to understand the disposition and toxicity of environmental pollutants and their biotransformation products, and for the analyses of products formed from template-directed synthesis of complex molecules in the solid state. The NMR spectrometer is also used to develop catalytic transformations and strategies for bond activation and to study boron-mediated chemistry, exemplified by nitrene formation to generate amines through carbon–hydrogen functionalization processes.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.