Antiinsectan Natural Products from Fungal Sclerotia

真菌次生代谢产物的化学研究 将研究菌核。 硬化症是关键的生理 对许多真菌的生存和繁殖至关重要的结构 物种 生态考虑和间接证据 表明菌核可能含有新抗虫代谢产物 在其他真菌组织中没有发现。 的发生 阻止食真菌动物进食的菌核代谢物 昆虫对真菌化学生态学具有重要意义。 将测试巩膜提取物对以下两种疾病的影响： 与生态有关的重要农业昆虫。 一 已经有一批抗虫提取物。 活性 将通过色谱法分离代谢物， 用现代光谱技术鉴定出来。 实验 以确定这些化合物是否 集中在菌核中。 调查还将 扩展到包括相关的真菌体（即，子囊层）。 这些研究将从根本上揭示 重要的，很少研究的方面，真菌次生 代谢，并将允许进一步探索这种独特的 新的抗虫天然产物的来源。 %% 有了这个奖项，有机合成计划将支持 James B博士的研究。他是爱荷华州大学的格劳尔。 博士 格洛尔将把他的研究重点放在一个专门的组织结构上 作为新的天然产物的来源 可能具有抗昆虫活性的化合物。 这有可能 有利于生物化学和农业的研究， 化学工业。

Chemical studies of secondary metabollities from fungal sclerotia will be studied. Sclerotia are key physiological structures vital to the survival and propagation of many fungal species. Ecological considerations and circumstantial evidence suggest that sclerotia may contain new antiinsectan metabolites not found in other fungal tissues. The occurrence of sclerotial metabolites that deter feeding by fungivorous insects would be very significant to fungal chemical ecology. Sclerotial extracts will be tested for effects against both ecologically relevant and agriculturally important insects. A pool of antiinsectan extracts is already available. Active metabolites will be isolated by chromatographic methods, and identified using modern spectroscopic techniques. Experiments will be performed to determine whether these compounds are concentrated in the sclerotia. Investigations will also be extended to include related fungal bodies (i.e., ascostromata). These studies will provide insight into fundamentally significant, rarely-studied aspects of fungal secondary metabolism, and will permit further exploration of this unique source of new antiinsectan natural products. %% With this award, the Organic Synthesis Program will support the research of Dr. James B. Gloer at the University of Iowa. Dr. Gloer will focus his research on a specialized tissue structure of fungi, the sclerotia, as a source of new natural products that may have antiinsectan activity. This has the potential to benefit research in biochemistry and agriculture as well as in the chemical industry.