Conference: Energy Landscapes of Proteins, Glasses and Clusters: Dynamics, Folding, Function and Prediction, to be held April 1-5, 2001 in San Diego, CA

布鲁克斯，III查尔斯L.MCB-0091839能量景观理论是发展蛋白质折叠的“新观点”的跳板。这个框架是负责我们不断增长的定量理解蛋白质折叠机制和详细的连接到实验探测foldingprocess。景观理论在集群和玻璃研究中的平行发展也显著地塑造了这一领域的理解。这两个不同领域之间思想和概念的交流促进了各自的发展。然而，更详细的交流和论坛讨论和提出基本的想法和问题将有助于这两个领域的持续发展。本次研讨会的目的是提供一个论坛，讨论折叠和眼镜和集群现象之间的共同主题，以促进这些社区之间的思想交流，调查的进展，标志着每个领域，如果没有新的理论和方法的整合，在这些研究领域所取得的令人兴奋的新进展是不可能的。计算化学和物理化学的实验进展已经成功地应用于分子生物学和生物化学。在这次研讨会上，我们将整合不同的团体，他们参与了这一跨学科的追求，旨在定量地了解折叠问题。2001年在圣地亚哥举行的ACS春季会议将为这一事件提供适当的论坛。

Brooks, III Charles L.MCB-0091839Energy landscape theory was the springboard for development of the "new view'" of proteinfolding. This framework is responsible for our growing quantitative understanding ofprotein folding mechanism and detailed connections to experiments probing the foldingprocess. Parallel development of landscape theory in the study of clusters and glasses hasalso significantly shaped understanding in this field. The interchange of ideas andconcepts between these two distinct areas has added to the growth of each. However, moredetailed exchanges and forums for discussion and presentation of underlying ideas andquestions will aid continuing development of both areas. The goal of this symposium is toprovide this forum for a discussion of common themes between folding and glasses andcluster phenomena, to promote the exchange of ideas between these communities, to surveythe advances that have hallmarked each area, and to point to the challenges that remain inboth.The exciting new advances that have taken place in these areas of investigation would havebeen impossible without the integration of the new theoretical and experimental advancesin computational chemistry and physical chemistry that have been successfully applied tomolecular biology and biochemistry. In this symposium, we will integrate the differentgroups that have taken part in shaping the successes this interdisciplinary persuit aimedat a quantitative understanding of the folding problem. The ACS Spring Meeting in 2001 atSan Diego will provide the appropriate forum for this event.