PECASE: Foundations of Autonomous Biomolecular Computation

EIA-0093486 Winfree，Erik加州理工学院PECASE：自主生物分子计算的基础该项目正在开发自主的、可编程的生化系统，该系统在微小的液滴中运行，以实现化学任务，如纳米结构制造。自主生物分子计算的理论模型，以实现这些模型的实验使用DNA分子，并定量表征个别分子的逻辑组件和更大的系统建立从他们正在执行。 除了DNA的特定背景之外，这项研究正在创建自主生物分子计算系统的原型，并探索纳米级计算中的基本鲁棒性问题，例如由于热噪声和扩散引起的物种和随机事件之间的串扰。该项目旨在利用他们对生物化学系统的先进控制，开始为可靠的分子计算建立更广泛的基础。正在开发两门新课程，向学生介绍开始生物分子计算工作所需的必要概念和工具。 该研究正在建立一个探索生物分子计算的实验系统，并为纳米级计算提供基础知识和原理，如计算模型，分子算法，物理极限，错误和纠错。 虽然生物分子系统是大规模并行的，异步的，随机的，很难设计，PI正在研究新的编程原则，导致分子计算科学。

EIA-0093486Winfree, ErikCalifornia Institute of TechnologyPECASE: Foundations of Autonomous Biomolecular ComputationThe project is developing autonomous, programmable biochemical systems that operate in a microscopic drop of liquid to achieve chemical tasks, such as nanostructure fabrication. Theoretical models of autonomous biomolecular computation to implement these models experimentally using DNA molecules, and to quantitatively characterize individual molecular logic components and the larger systems built from them are being performed. Beyond the specific context of DNA, this research is creating a prototype of autonomous biomolecular computing systems and explore fundamental robustness issues in nanoscale computing, such as cross-talk between species and stochastic events due to thermal noise and diffusion. The project is aiming to leverage their advanced control over biochemical systems to begin establishing a broader foundation for reliable molecular computing.Two new courses are being developed introducing students to the necessary concepts and tools required to begin work in biomolecular computation. This research is establishing an experimental system for exploring computation by biological molecules, and is providing fundamental knowledge and principles for nanoscale computation, such as models of computation, molecular algorithms, physical limits, errors and error correction. Although biomolecular systems are massively parallel, asynchronous, stochastic, and hard to design, the PI is researching on new programming principles, leading to a science of molecular computation.