New Transition Metal Catalyzed Annulation Chemistry

建议的研究方向是发展过渡金属催化环化方法，用于合成多取代芳烃，杂芳烃和用于制备共轭聚合物的单体。由区域控制的钯催化的炔-炔[4+2]苄基环化反应引发的顺序环加成/环化反应可生成缩合芳香体系。使用偶氮炔或偶氮亲炔类似地导致吡啶衍生物。聚取代芳烃体系的各种相关合成路线为合成聚苯乙烯提供了单体，并适用于构建各种类别的天然产物。有了这个奖项，有机合成项目支持了芝加哥伊利诺伊大学化学系Vladimir Gevorgyan教授的研究。Gevorgyan教授正在发现和开发合成环和多环有机分子的新技术，这些分子代表了许多生物和药理活性化合物的核心结构。简单的前体通过连续反应的自发级联有效地转化为所需的目标结构，提供了不同寻常和适应性强的新合成方法。这些合成路线也适用于制备一类已知具有重要电学和光学性质的聚合物的前体。

The proposed studies are directed toward the development of transition metal catalyzed annulation methodologies for the synthesis of polysubstituted aromatics, heteroaromatics, and monomers for the preparation of conjugated polymers. Sequential cycloaddition/cyclization reactions, triggered by regiocontrolled palladium-catalyzed enyne-yne [4+2] benzannulation, afford condensed aromatic systems. Use of aza-enynes or aza-enynophiles similarly leads to pyridine derivatives. Various related synthetic routes to polysubstituted aromatic systems afford monomers for the synthesis of poly(phenyleneethylene)s and are applicable to the construction of a variety of classes of natural products.With this award, the Organic Synthesis Program supports the studies of Professor Vladimir Gevorgyan, of the Department of Chemistry at the University of Illinois at Chicago. Professor Gevorgyan is discovering and developing new techniques for the synthesis of cyclic and polycyclic organic molecules which represent the core structures of numerous biologically and pharmacologically active compounds. Simple precursors are efficiently converted to the desired target structures through spontaneous cascades of sequential reactions, affording unusual and adaptable new synthetic approaches. These synthetic routes are also applicable to the preparation of precursors for a class of polymers known to display significant electrical and optical properties.