Novel Transition Metal Catalyzed Synthetic Transformations

在这个项目中，Gevorgyan博士正在开发新的过渡金属催化方法来合成含有环结构的有机分子。现有的合成这些分子的方法产生不需要的副产品作为废物和/或需要昂贵的试剂，因此，这些方法的广泛应用往往受到限制。为了解决这个问题，Gevorgyan博士和他在伊利诺伊大学芝加哥分校的研究小组正在研究一种新的催化方法，用于选择性、高效和通用的有机环结构的构建。所提出的工作的更广泛的影响是为构建块分子提供了新的和有效的途径，这些分子在生物学和材料科学等不同领域都很重要，在这些领域，它们被用于组装更复杂的分子和材料。此外，这项研究大大降低了化学品的成本，产生的废物更少，因此，这项研究生产的化学品对环境的影响更小。此外，Gevorgyan博士积极参与从芝加哥城市学院招募少数民族本科生进行研究的外展活动。在UIC，学生参与研究旨在释放学生的潜在才能和创造力，增加他们在大学的保留率，并增加他们的职业可能性。在这个由化学部门化学合成项目资助的项目中，芝加哥伊利诺伊大学化学系的Gevorgyan博士正在开发一套新的迁移环异构化和环加成协议，用于多取代碳和杂环分子的组装。项目内容包括以下几个方面：(1)开发新的碳杂环核迁移环异构化反应；(2)向密集取代的芳香分子迁移并环反应的发展；(3)创新转位反应的发展；(4)新型跨环反应的发展。人们相信，这些创新的反应允许分子复杂性的急剧增加，从而使简单的前体容易获得重要的、密集取代的框架。这个项目是有机金属化学和有机化学与催化的交叉点，为本科生和研究生提供多学科培训，因此对他们的继续教育有广泛的影响。此外，Gevorgyan博士还积极参与从芝加哥城市学院招募少数民族本科生的外展活动。

In this project, Dr. Gevorgyan is developing novel transition metal-catalyzed methods to synthesize organic molecules with structures containing rings. Existing methods to synthesize these molecules produce unwanted by-products as waste and/or require expensive reagents, and thus, the broad application of these methodologies is often limited. To address this problem, the development of novel catalytic methods for the selective, efficient, and general construction of organic ring structures is being pursued by Dr. Gevorgyan and his research group at University of Illinois-Chicago. The broader impacts of the proposed work are providing new and effective routes to building block molecules of importance to areas as diverse as biology and materials science, where they are utilized in the assembly of more complex molecules and materials. Moreover, this research is dramatically reducing the cost of chemicals and producing less waste, and thus, this research produces chemicals with less environmental impact. In addition, Dr. Gevorgyan is actively engaging in outreach activities for recruiting minority undergraduate students from Chicago City Colleges into research. Student involvement in research at UIC is projected to unlock the students' potential talents and creativity, increase their retention in College, and enhance their career possibilities.In this project, funded by the Chemical Synthesis Program of the Chemistry Division, Dr. Gevorgyan of the Department of Chemistry at the University of Illinois at Chicago is developing a set of novel migratory cycloisomerization and cycloaddition protocols toward assembly of multisubstituted carbo- and heterocyclic molecules. The project includes several aspects: (1) development of novel migratory cycloisomerization reactions toward fused carbo- and heterocyclic cores; (2) development of migratory benzannulation reactions toward densely substituted aromatic molecules; (3) development of innovative transposition reactions; and (4) development of new types of transannulation reaction. It is believed that these innovative reactions allow for a dramatic increase of molecular complexity, thus giving easy access to important, densely-substituted frameworks from simple precursors. This project, which is at the interface of organometallic and organic chemistry and catalysis is providing multidisciplinary training at undergraduate and graduate levels, and thus has a broad impact on their continuing education. In addition, Dr. Gevorgyan is actively engaging in outreach activities for recruiting minority undergraduate students from Chicago City Colleges.