Novel Transition Metal Catalyzed Synthetic Transformations

新型过渡金属催化合成转化

• 批准号: 1936422
• 负责人: Vladimir Gevorgyan
• 金额: $ 20.5万
• 依托单位: University of Texas at Dallas
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-06-01 至 2020-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1936422&HistoricalAwards=false
• 关键词: Novel; Transition; Metal; Catalyzed; Synthetic

In this project, Dr. Gevorgyan is developing novel transition metal-catalyzed methods to synthesize organic molecules with structures containing rings. Existing methods to synthesize these molecules produce unwanted by-products as waste and/or require expensive reagents, and thus, the broad application of these methodologies is often limited. To address this problem, the development of novel catalytic methods for the selective, efficient, and general construction of organic ring structures is being pursued by Dr. Gevorgyan and his research group at University of Illinois-Chicago. The broader impacts of the proposed work are providing new and effective routes to building block molecules of importance to areas as diverse as biology and materials science, where they are utilized in the assembly of more complex molecules and materials. Moreover, this research is dramatically reducing the cost of chemicals and producing less waste, and thus, this research produces chemicals with less environmental impact. In addition, Dr. Gevorgyan is actively engaging in outreach activities for recruiting minority undergraduate students from Chicago City Colleges into research. Student involvement in research at UIC is projected to unlock the students' potential talents and creativity, increase their retention in College, and enhance their career possibilities.In this project, funded by the Chemical Synthesis Program of the Chemistry Division, Dr. Gevorgyan of the Department of Chemistry at the University of Illinois at Chicago is developing a set of novel migratory cycloisomerization and cycloaddition protocols toward assembly of multisubstituted carbo- and heterocyclic molecules. The project includes several aspects: (1) development of novel migratory cycloisomerization reactions toward fused carbo- and heterocyclic cores; (2) development of migratory benzannulation reactions toward densely substituted aromatic molecules; (3) development of innovative transposition reactions; and (4) development of new types of transannulation reaction. It is believed that these innovative reactions allow for a dramatic increase of molecular complexity, thus giving easy access to important, densely-substituted frameworks from simple precursors. This project, which is at the interface of organometallic and organic chemistry and catalysis is providing multidisciplinary training at undergraduate and graduate levels, and thus has a broad impact on their continuing education. In addition, Dr. Gevorgyan is actively engaging in outreach activities for recruiting minority undergraduate students from Chicago City Colleges.

在这个项目中，Gevorgyan博士正在开发新的过渡金属催化方法来合成具有含环结构的有机分子。合成这些分子的现有方法产生不需要的副产物作为废物和/或需要昂贵的试剂，因此，这些方法的广泛应用通常受到限制。为了解决这个问题，Gevorgyan博士和他在伊利诺伊大学芝加哥分校的研究小组正在开发用于选择性、有效和一般性地构建有机环结构的新型催化方法。拟议工作的更广泛影响正在为构建模块分子提供新的有效途径，这些分子对生物学和材料科学等不同领域具有重要意义，它们被用于组装更复杂的分子和材料。此外，这项研究大大降低了化学品的成本，产生的废物更少，因此，这项研究产生的化学品对环境的影响更小。此外，Gevorgyan博士还积极参与外展活动，招募来自芝加哥城市学院的少数民族本科生参加研究。学生参与UIC的研究，预计将释放学生的潜在才能和创造力，提高他们在大学的保留率，并提高他们的职业发展机会。在这个项目中，由化学系化学合成计划资助，伊利诺伊大学芝加哥分校化学系的Gevorgyan博士正在开发一套新的迁移环异构化和环加成方案，以组装多取代的碳和杂环分子。该项目包括几个方面：（1）开发新的迁移性环异构化反应，以稠合碳和杂环为核心;（2）开发迁移性苯并环化反应，以密集取代的芳香族分子;（3）开发创新的转座反应;（4）开发新型的转环反应。据信，这些创新的反应允许分子复杂性的急剧增加，从而使简单的前体容易获得重要的，密集取代的框架。该项目是有机金属和有机化学与催化的接口，提供本科生和研究生一级的多学科培训，因此对他们的继续教育产生广泛影响。此外，Gevorgyan博士还积极参与外展活动，从芝加哥城市学院招收少数民族本科生。

项目成果

Visible‐Light‐Induced Palladium‐Catalyzed Generation of Aryl Radicals from Aryl Triflates

可见光——光诱导钯——催化从芳基三氟甲磺酸酯生成芳基自由基

• DOI: 10.1002/ange.201915962
• 发表时间: 2020
• 期刊: Angewandte Chemie
• 作者: Ratushnyy, Maxim;Kvasovs, Nikita;Sarkar, Sumon;Gevorgyan, Vladimir
• 通讯作者: Gevorgyan, Vladimir

Photoinduced Palladium-Catalyzed Carbofunctionalization of Conjugated Dienes Proceeding via Radical-Polar Crossover Scenario: 1,2-Aminoalkylation and Beyond

• DOI: 10.1021/jacs.0c03993
• 发表时间: 2020-06-03
• 期刊: JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
• 影响因子: 15
• 作者: Cheung, Kelvin Pak Shing;Kurandina, Daria;Gevorgyan, Vladimir
• 通讯作者: Gevorgyan, Vladimir