Novel Transition Metal Catalyzed Synthetic Transformations

在这个项目中，Gevorgyan博士正在开发新的过渡金属催化方法来合成具有含环结构的有机分子。现有的合成这些分子的方法会产生不想要的副产品作为废物和/或需要昂贵的试剂，因此，这些方法的广泛应用往往受到限制。为了解决这个问题，伊利诺伊大学芝加哥分校的Gevorgyan博士和他的研究小组正在开发新的催化方法，用于选择性、高效和一般地构建有机环结构。拟议工作的更广泛影响是提供了新的有效途径，以构建对生物学和材料科学等不同领域具有重要意义的块状分子，在这些领域，它们被用于组装更复杂的分子和材料。此外，这项研究大大降低了化学品的成本，产生的废物更少，因此，这项研究生产的化学品对环境的影响更小。此外，Gevorgyan博士正在积极参与从芝加哥城市学院招收少数族裔本科生进行研究的外展活动。学生参与UIC的研究预计将释放学生的潜力和创造力，增加他们在大学里的留存，并增强他们的职业前景。在这个由化学系化学合成计划资助的项目中，芝加哥伊利诺伊大学化学系的Gevorgyan博士正在开发一套新的迁移环异构化和环加成协议，用于组装多取代碳环和杂环分子。该项目包括几个方面：(1)开发新型的向稠合碳环和杂环核的迁移环异构化反应；(2)向密集取代的芳香族分子开发迁移苯环反应；(3)开发创新的转置反应；以及(4)开发新型的跨环反应。人们认为，这些创新的反应允许分子复杂性的急剧增加，从而使人们可以很容易地从简单的前体获得重要的、密集取代的骨架。该项目处于有机金属和有机化学与催化的交界处，为本科生和研究生提供多学科培训，因此对他们的继续教育产生了广泛的影响。此外，Gevorgyan博士正在积极参与从芝加哥城市学院招收少数族裔本科生的外展活动。

In this project, Dr. Gevorgyan is developing novel transition metal-catalyzed methods to synthesize organic molecules with structures containing rings. Existing methods to synthesize these molecules produce unwanted by-products as waste and/or require expensive reagents, and thus, the broad application of these methodologies is often limited. To address this problem, the development of novel catalytic methods for the selective, efficient, and general construction of organic ring structures is being pursued by Dr. Gevorgyan and his research group at University of Illinois-Chicago. The broader impacts of the proposed work are providing new and effective routes to building block molecules of importance to areas as diverse as biology and materials science, where they are utilized in the assembly of more complex molecules and materials. Moreover, this research is dramatically reducing the cost of chemicals and producing less waste, and thus, this research produces chemicals with less environmental impact. In addition, Dr. Gevorgyan is actively engaging in outreach activities for recruiting minority undergraduate students from Chicago City Colleges into research. Student involvement in research at UIC is projected to unlock the students' potential talents and creativity, increase their retention in College, and enhance their career possibilities.In this project, funded by the Chemical Synthesis Program of the Chemistry Division, Dr. Gevorgyan of the Department of Chemistry at the University of Illinois at Chicago is developing a set of novel migratory cycloisomerization and cycloaddition protocols toward assembly of multisubstituted carbo- and heterocyclic molecules. The project includes several aspects: (1) development of novel migratory cycloisomerization reactions toward fused carbo- and heterocyclic cores; (2) development of migratory benzannulation reactions toward densely substituted aromatic molecules; (3) development of innovative transposition reactions; and (4) development of new types of transannulation reaction. It is believed that these innovative reactions allow for a dramatic increase of molecular complexity, thus giving easy access to important, densely-substituted frameworks from simple precursors. This project, which is at the interface of organometallic and organic chemistry and catalysis is providing multidisciplinary training at undergraduate and graduate levels, and thus has a broad impact on their continuing education. In addition, Dr. Gevorgyan is actively engaging in outreach activities for recruiting minority undergraduate students from Chicago City Colleges.